Rebirth Items
<3
ItemID: 15
"HP up"
• +1 Health Up
• Fully restores all red heart containers
• Has a chance to drop from the Gluttony miniboss fight.
Type: Passive
Item Pool: Item Room, Boss Room, Gluttony Miniboss
???'s Only Friend
ItemID: 320
"Controlled friend"
• A familiar fly that can be moved around via use of the arrow keys dealing 2.5 contact damage per tick, similar to the Ludovico Technique's mechanic.
• Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.
UNLOCK: Unlock this item by beating Boss Rush with Blue Baby.
Type: Passive, Familiar
Item Pool: Item Room
1UP
ItemID: 11
"Extra life"
• Gives the player an extra life
• When revived, the green mushroom that follows Isaac will disappear and he will respawn with the same amount of red heart containers at full health.
• Resurrection takes place before all other items which give you an extra live, except Guppy's Collar.
Type: Passive
Item Pool: Secret Room
20/20
ItemID: 245
"Double shot"
• Isaac now shoots from both eyes at the same time.
• Unlike the Inner Eye and Mutant Spider items, this double shot item does not give a tears down, effectively giving you double damage per second potential.
Type: Passive, Tear Modifier
Item Pool: Item Room
3 Dollar Bill
ItemID: 191
"Rainbow tears"
• Random tear effect for every room.
• Possible tear effects: Fire Mind, Spoon Bender, My Reflection, Ouija Board, 20/20, Inner Eye, Iron Bar, Death's Touch, Tough Love, Proptosis, Number One, Mom's Contacts or Dark Matter.
In Afterbirth this item gives a random tear effect every few seconds, not every room.
Type: Passive, Tear Modifier
Item Pool: Item Room
9 Volt
ItemID: 116
"Quicker charge"
• Automatically gives you 1 bar of charge after using your spacebar item.
• Fully recharges your current spacebar item when picked up.
• Causes the Sharp Plug item to become useless due to the fact that you can never have 0 charge on your spacebar item.
• Any items which are normally a 1 room recharge are now timed instead.
Type: Passive
Item Pool: Shop
Abaddon
ItemID: 230
"Evil up + DMG up + fear shot"
• On pickup removes all of your red hearts and gives you 6 black hearts.
• +1.5 Damage Up.
• +0.2 Speed Up.
• Tears now have a chance to induce the fear effect, causing enemies to run away from Isaac for a short period.
• The chance to fear enemies is affected by your luck stat and at +85 Luck it will activate every time.
• When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.
UNLOCK: Unlock this item by beating the Chest with Azazel.
Type: Passive
Item Pool: Devil Room
Abel
ItemID: 188
"Mirrored buddy"
• A familiar that mirrors the player's movements and shoots tears directly at Isaac.
• Abel's tears do the same as Isaac's base damage (3.5).
• In larger rooms, Abel will mirror to the other side of the screen instead of the entire room.
UNLOCK: Unlock this item by beating the Dark Room with Cain.
Type: Passive, Familiar
Item Pool: Item Room, Gold Chest
Anarchist's Cookbook
ItemID: 65
"Summon bombs"
• Spawns troll bombs at random locations around the room.
• Bombs are effected by other passive bomb items.
• Has a chance to drop from the Pride miniboss fight.
Type: Active
Recharge Time: 3 rooms.
Item Pool: Item Room, Library, Pride Miniboss
Anemic
ItemID: 214
"Toxic blood"
• +5 Range Up.
• When Isaac takes damage, he will start to leave a trail of blood creep behind him as he walks for the current room.
• Lazarus' revived form (Lazarus II) respawns with this item.
Type: Passive
Item Pool: Item Room
Ankh
ItemID: 161
"Eternal life?"
• Upon death, the player respawns as Blue Baby with three Soul hearts.
• This is a one time use item and all new heart containers will be soul hearts.
• Can be used to unlock some of Blue Baby's secrets before having the character available.
Type: Passive
Item Pool: Item Room
Anti-Gravity
ItemID: 222
"Antigravity tears + tears up"
• -2 Tear Delay (Tears Up).
• As you hold down the fire button, shots will float in the same place until you release the fire key again.
• Allows you to store up a lot of tears in the air and release them all at once.
• When the tears are released, they will fire off in the direction that Isaac was originally facing when it was created.
Type: Passive, Tear Modifier
Item Pool: Item Room
Aquarius
ItemID: 308
"A trail of tears"
• Leaves a trail of tears on the floor behind Isaac which damages enemies that walk over it for 2 damage per tick.
• One of the twelve zodiac items available in the game.
Type: Passive
Item Pool: Item Room
Aries
ItemID: 300
"Ramming speed"
• +0.25 Speed up.
• Gives huge horns which stick out, allowing you to deal 18 contact damage if you hit something with enough speed.
• Will not deal contact damage unless you are moving fast enough, but does not prevent you from taking damage yourself.
• One of the twelve zodiac items available in the game.
Type: Passive
Item Pool: Item Room
Ball of Bandages
ItemID: 207
"Gotta lick em all"
• Gives Isaac an orbital ball of bandages that deals 7 contact damage per tick. Unlike the Cube of Meat, it does not block enemy shots.
• Collecting a second Ball of Bandages in the run turns the orbital into a pink head that shoots tears that deal 7 damage each and have a chance to charm enemies.
• Getting a third Ball of Bandages will transform the head into bandage girl which will chase enemies dealing 3.5 contact damage per tick while firing charm tears.
• A fourth Ball of Bandages will make the Bandage Girl bigger and stronger, making her deal 5.5 damage per tick instead.
• Any further Ball of Bandages will repeat the cycle.
• Charmed enemies will prioritize attacking other enemies in the room, otherwise they will still attack Isaac.
In Afterbirth this orbital can now block shots, making it equal to the Cube of Meat.
Type: Passive, Orbital
Item Pool: None (Horsemen boss only)
Ball of Tar
ItemID: 231
"Sticky feet..."
• Isaac leaves a trail of tar behind him which will slow down enemies that walk over it.
• Tears have a chance to slow enemies and their projectiles for a short period of time.
• The chance to slow enemies can improve based on your luck stat and will always slow enemies at +18 Luck.
Type: Passive
Item Pool: Item Room
The Battery
ItemID: 63
"Stores energy"
• All spacebar items can now be 'overcharged', allowing them to be charged up twice instead of once.
• The extra charges appear in yellow on top of the normal green bars.
• Has no effect with items which recharge over time instead of on a per-room basis.
Type: Passive
Item Pool: Shop
BBF
ItemID: 272
"Big beautiful fly"
• A large familiar black fly that bounces around the room, exploding on contact with enemies dealing 70 damage.
• Does not explode if it hits Isaac, however if it explodes on an enemy while Isaac is in range, he will take damage.
• Respawns after 10 seconds or by moving to another room.
• Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.
Type: Passive, Familiar
Item Pool: Item Room
The Bean
ItemID: 111
"Toot on command"
• Upon use, this item causes Isaac to fart and poison any enemies in close proximity.
• The Bean deals 26 damage total (5 initially then 21 in a Damage over Time effect.
Type: Active
Recharge Time: 1 room.
Item Pool: Item Room, Beggar
The Belt
ItemID: 28
"Speed up"
• +0.3 Speed Up.
Type: Passive
Item Pool: Boss Room
Best Bud
ItemID: 274
"Sworn protector"
• When Isaac takes damage, a white attack fly will spawn that orbits him at a similar distance to the Distant Admiration fly.
• The fly orbits a lot faster than Distant Admiration or Forever Alone and deals 5 damage per tick.
• Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.
Type: Passive, Orbital
Item Pool: Item Room, Key Beggar
Best Friend
ItemID: 136
"Friends 'till the end"
• Places a decoy on the floor which attracts enemies and explodes after a period of time.
• When it explodes, it deals 110 damage to everything in radius (Same damage as Mr Mega bombs).
Type: Active
Recharge Time: 3 rooms.
Item Pool: Item Room
BFFS!
ItemID: 247
"Your friends rule!"
• Makes all of Isaac's familiars much bigger, making them deal more damage.
• Causes all familiars to deal double damage (x2 / +100%).
• Has no effect on Rotten Baby, which instead benefits from Hive Mind.
Type: Passive
Item Pool: Shop, Key Beggar
The Bible
ItemID: 33
"Temporary flight"
• Gives Isaac angel wings for the current room, allowing him to fly.
• If used during the Mom's Foot or Mom's Heart boss fights, The Bible will kill Mom instantly.
• If used during the Satan fight, The Bible will instantly kill Isaac.
Type: Active
Recharge Time: 6 rooms.
Item Pool: Shop, Library, Angel Room
Big Fan
ItemID: 279
"Fat protector"
• A very large orbital that moves around Isaac very slowly, blocking shots and dealing 2 contact damage per tick.
• Affects the speed of all other orbitals, slowing them down a lot (NOTE: This effect does not happen until you get a new orbital after Big Fan).
• Does not count as one of your three standard orbitals, allowing you to have a total of 4.
• Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.
Type: Passive, Orbital
Item Pool: Item Room
The Black Bean
ItemID: 180
"Toot on touch"
• Upon taking damage, Isaac will fart, causing all enemies in close proximity to become poisoned.
• Black Bean deals 26 damage total (5 initially then 21 in a Damage over Time effect.
Type: Passive
Item Pool: Item Room, Beggar
Black Candle
ItemID: 260
"Curse of immunity + evil up"
• +1 Black Heart.
• Immunity to all floor curses (e.g. Curse of the Lost)
• When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.
• An item that can appear in the shop room or in a Curse Room.
• +30% Higher chance of a Devil Deal opening after the boss fight.
UNLOCK: Unlock this item by donating 150 pennies to the Shop.
Type: Passive
Item Pool: Shop, Curse Room
Black Lotus
ItemID: 226
"HP up x3"
• +1 Health Up.
• +1 Soul Heart.
• +1 Black Heart.
• When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.
• An item only found in the secret room pool.
Type: Passive
Item Pool: Secret Room
Blank Card
ItemID: 286
"Card Mimic"
• When used, copies the effect of the tarot card you are currently holding without consuming it.
• The Blank Card can also be used to mimic mystic runes as well as tarot cards.
• An item that often appears in the shop.
UNLOCK: Unlock this item by beating the Isaac boss with Eden.
In Afterbirth using this with the ? card will teleport you to the I AM ERROR room.
Type: Active
Recharge Time: 4 rooms.
Item Pool: Item Room, Shop, Secret Room
Blood Bag
ItemID: 119
"HP up"
• +1 Health Up
• +0.3 Speed Up
• Heals for 5 full red hearts.
• Has a chance to drop while playing any Blood Donation machine.
UNLOCK: Unlock this item by playing the Blood Donation machine 30 times.
Type: Passive
Item Pool: None (Blood Donation machine only)
Blood Clot
ItemID: 254
"DMG + range up"
• +1.0 Damage Up (Left eye only).
• +5 Range Up (Left eye only).
• The above stats only apply to tears fired from Isaac's left eye or with a 50% chance if you have an item which causes you to fire from a single source only.
Type: Passive
Item Pool: Boss Room
Blood of the Martyr
ItemID: 7
"DMG up"
• +1.0 Damage Up.
• +50% / 1.5 times Damage Multiplier if you also have Book of Belial (Does not stack with Magic Mushroom or Cricket's Head multipliers)
• This item can only be found in the item room pool, unlike the original game where it was also a god item
Type: Passive
Item Pool: Item Room
Blood Rights
ItemID: 186
"Mass enemy damage at a cost"
• Upon use, takes away one full heart and deals 40 damage to the entire room.
• With the Isaac's Heart item, you can use Blood Rights without taking damage.
UNLOCK: Unlock this item by beating Satan with Samson.
Type: Active
Recharge Time: Instant.
Item Pool: Item Room
Bloody Lust
ItemID: 157
"RAGE!"
• Each time you take damage, you gain a damage up which lasts for the rest of the floor and turn a darker red colour each time.
• After taking 6 hits you will cap at +6.5 Damage for the rest of the floor.
• Damage given for each hit increases as follows: +0.5, +0.5, +0.5, +1.66, +1.66, +1.66.
• Bloody lust works differently in Rebirth - Damage is given for taking damage and is persistent for the entire floor.
UNLOCK: Unlock this item by beating the Isaac boss with Samson.
Type: Passive
Item Pool: Item Room
Blue Cap
ItemID: 342
"HP + tears + shot speed down"
• +1 Health Up.
• +0.7 Tears Up.
• -0.16 Shot Speed Down.
• An item only found in the Boss Room pool.
Type: Passive
Item Pool: Boss Room
Blue Map
ItemID: 246
"Secrets"
• Reveals the locations of the secret and super secret room for the current floor and all future floors.
UNLOCK: Unlock this item by donating 10 pennies to the Shop.
Type: Passive
Item Pool: Shop, Beggar, Key Beggar
Bob's Brain
ItemID: 273
"Explosive thoughts"
• A green brain that launches in the direction you are firing your tears and will explode on contact with enemies, dealing damage and poisoning anything in the blast radius.
• Bob's Brain can deal anywhere between 67.5 - 69.5 damage (63.5 on hit then 4 or 6 as damage over time poison) and this will scale with further bomb upgrade items.
• Regenerates over time.
• Will hurt Isaac if he is in the blast radius.
Type: Passive, Familiar
Item Pool: Item Room, Gold Chest
Bob's Curse
ItemID: 140
"Poison bombs"
• All of Isaac's bombs now leave a poison effect on any enemies within the blast radius.
• +5 Bombs.
• As well as dealing the standard 60 damage for a bomb, it will apply a Damage over Time effect that does 4 or 6 damage per tick.
• Has a chance to drop from the Super Sloth miniboss fight.
Type: Passive
Item Pool: Item Room, Super Sloth Miniboss
Bob's Rotten Head
ItemID: 42
"Reusable ranged bomb"
• A poison bomb which can be thrown and leaves a poison effect on any enemies within the blast radius.
• The bomb deals 50 damage on hit and leaves a damage over time poison effect that does 6 or 8 damage per tick.
• Synergizes with tear modifying items such as My Reflection or Tiny Planet.
• Has a chance to drop from the Sloth miniboss fight.
Type: Active
Recharge Time: 3 rooms
Item Pool: Item Room, Gold Chest, Sloth Miniboss
Bobby - Bomb
ItemID: 125
"Friends till the end"
• All of Isaac's bombs now having a homing effect when placed on the floor.
• +5 Bombs.
Type: Passive
Item Pool: Item Room
The Body
ItemID: 334
"I feel all"
• +3 Health Up.
• The three heart containers are pre-filled with red hearts.
UNLOCK: Unlock this item by beating the Chest with The Lost.
Type: Passive
Item Pool: Item Room, Angel Room
Bogo Bombs
ItemID: 250
"1+1 bombs"
• All bomb pickups are now 1+1 bombs.
• An item only found in the Shop item pool.
Type: Passive
Item Pool: Shop
Bomb Bag
ItemID: 131
"Gives bombs"
• A bag of bombs that will drop a bomb pickup every 2 rooms.
UNLOCK: Unlock this item by beating Satan with Cain.
Type: Passive, Familiar
Item Pool: Item Room, Secret Room
The Book of Belial
ItemID: 34
"Temporary DMG up"
• Upon use, gives +2 damage up which lasts for the current room.
• +50% / 1.5 times Damage Multiplier if you also have Blood of the Martyr (Does not stack with Magic Mushroom or Cricket's Head multipliers).
• Guaranteed Devil or Angel Room if you have it when you kill the boss on all floors where it's possible to get one.
• Judas starts with this item.
In Afterbirth this is no longer a Guaranteed Devil Deal chance, instead it is +12.5%
Type: Active
Recharge Time: 3 rooms
Item Pool: Library, Devil Room
Book of Revelations
ItemID: 78
"Reusable soul protection"
• Upon use, gives Isaac an extra Soul heart.
• Using this item gives you a higher chance of finding a horsemen boss at the end of the floor.
• +25% chance of a Devil Deal opening after the boss fight (Exact chance unknown).
UNLOCK: Unlock this item by beating one of the horsemen bosses for the first time.
In Afterbirth this item gives +17.5% devil deal chance instead of +25%
Type: Active
Recharge Time: 6 rooms
Item Pool: Item Room, Library
Book of Secrets
ItemID: 287
"??????"
• When used, you have a chance of getting one of the three following effects: Treasure Map (floor layout), Compass (map icons) or Blue Map (secret room locations)
UNLOCK: Unlock this item by beating Satan with Eden.
Type: Active
Recharge Time: 6 rooms
Item Pool: Item Room, Library, Secret Room
Book of Shadows
ItemID: 58
"Temporary invincibility"
• Gives the player an invulnerability effect which lasts for a few seconds.
Type: Active
Recharge Time: 3 rooms
Item Pool: Item Room, Library
The Book of Sin
ItemID: 97
"Reusable item generator"
• Spawns a random pickup on the floor.
• The possible pickups from this item include: Bombs, hearts, keys, coins, pills, batteries or tarot cards.
UNLOCK: Unlock this item by beating each of the Seven Sins once.
Type: Active
Recharge Time: 4 rooms
Item Pool: Item Room, Library, Devil Room
Boom!
ItemID: 19
"10 bombs"
• +10 Bombs
Type: Passive
Item Pool: Item Room
Boomerang
ItemID: 338
"It will never leave you"
• A blue boomerang which can be thrown in a similar fashion to Mom's Knife, to stun any enemies it hits and deal damage.
• The damage dealt by the Boomerang is equal to double your tear damage.
• The boomerang can also be used to grab pickups and consumables from a distance, similar to the legend of zelda boomerang.
• The range of the boomerang is affected by range, with number one the distance is very short and makes the item a lot less effective.
Type: Active
Recharge Time: Timed (A few seconds)
Item Pool: Shop
Box
ItemID: 198
"Stuff"
• Spawns one of each type of pickup.
• Pickups spawned: 1 heart, 1 key, 1 bomb, 1 coin, 1 card, 1 pill and 1 trinket.
Type: Passive
Item Pool: Boss Room, Challenge Room
Box of Spiders
ItemID: 288
"It's a box of spiders"
• When used, spawns 2-4 friendly blue spiders on the floor.
• Blue Spiders do 2.5x of Isaac's damage.
Type: Active
Recharge Time: 2 rooms
Item Pool: Item Room
Breakfast
ItemID: 25
"HP up"
• +1 Health Up.
Type: Passive
Item Pool: Boss Room, Challenge Room, Beggar
Breath of Life
ItemID: 326
"Invincibility at a cost"
• While you hold the spacebar down with this item, it will de-charge gradually and when the charge bar gets to zero it will grant you a brief period of invincibility.
• If the spacebar is held for too long (about 1 second) when it has no charge, you will take damage.
Type: Active
Recharge Time: Timed (1 bar per second)
Item Pool: Angel Room
Brimstone
Special item
ItemID: 118
"Blood laser barrage"
• Tears are replaced with the ability to charge and fire a powerful laser that travels in a straight line across the room, dealing a lot of damage (damage * 13) to any enemies it comes into contact with.
• Does not directly affect your Damage stat but hits enemies 13 times per charge, spawning Guppy flies with every hit.
• Synergizes very well with a lot of items including Tammy's Head, Tiny Planet, Inner Eye (Triple Shot), Mutant Spider (Quad Shot) and many others.
• An item only found in the devil room pool (Note: The Fallen boss pulls items from the Devil Room Pool)
Type: Passive, Tear Modifier
Item Pool: Devil Room
Broken Watch
ItemID: 337
"I think its broken"
• Upon entering a new room, you now have a chance to randomly slow down or speed up all enemies in the room.
• An item only found in the Shop item pool.
Type: Passive
Item Pool: Shop
Brother Bobby
ItemID: 8
"Friends 'till the end"
• A familiar which follows Isaac and shoots normal tears which do 3.5 damage.
• Brother Bobby fires tears at a rate of 1 tear per second.
Type: Passive, Familiar
Item Pool: Item Room, Devil Room
Bucket of Lard
ItemID: 129
"HP up"
• +2 Health Up.
• -0.2 Speed Down.
• Of the two heart containers given from this item, only 1/2 a red heart of them is filled.
• Has a chance to drop from the Super Gluttony miniboss fight.
Type: Passive
Item Pool: Item Room, Super Gluttony Miniboss
Bum Friend
ItemID: 144
"He's Greedy"
• A beggar who follows Isaac around and automatically picks up nearby coins. After picking up a coin he has a random chance to drop pickups, including hearts, keys, bombs, coins, pills, cards or trinkets.
In Afterbirth this is one of the 3 items required to create the Super Bum familiar transformation.
Type: Passive, Familiar
Item Pool: Item Room
Butt Bombs
ItemID: 209
"Toxic blast +5 bombs"
• +5 bombs.
• Bombs now become poop bombs, which deal 10 damage to all enemies in the room and daze them for a short period of time.
Type: Passive
Item Pool: Item Room
Butter Bean
ItemID: 294
"Reusable knockback"
• When used, farts on nearby enemies and knocks them backwards away from Isaac.
• Allows you to reflect projectiles away from Isaac (Afterbirth only feature)
UNLOCK: Unlock this item by destroying 100 poops.
Type: Active
Recharge Time: Timed (A few seconds)
Item Pool: Item Room, Beggar
Caffeine Pill
ItemID: 340
"Speed up + size down"
• +0.3 Speed Up.
• Player Size Down.
• Gives you a random pill when picked up.
• An item only found in the boss room pool.
Type: Passive
Item Pool: Boss Room
Cain's Other Eye
ItemID: 319
"Near sighted friend"
• A familiar eye that bounces around the room slowly and fires tears in the same direction as Isaac.
• Cain's Other Eye deals scaling damage equal to Isaac's tear damage.
UNLOCK: Unlock this item by beating Boss Rush with Cain.
Type: Passive, Familiar
Item Pool: Item Room
Cancer
ItemID: 301
"HP up + you feel protected"
• +3 Soul Hearts
• After getting hit once, you gain a damage reduction for the rest of the room similar to The Wafer item (-50% damage taken).
• One of the twelve zodiac items available in the game.
Type: Passive
Item Pool: Item Room
The Candle
ItemID: 164
"Reusable flame"
• A spacebar item which allows Isaac to fire a blue flame that damages anything in its path for 23 damage per tick.
• Can cause up to a total of 184 potential damage.
UNLOCK: Unlock this item by donating 900 coins to the Shop.
Type: Active
Recharge Time: Timed (A few seconds)
Item Pool: Shop
Capricorn
ItemID: 307
"All stats up"
• +1 Health Up.
• +0.5 Damage Up.
• -1 Tear Delay (Tears Up).
• +0.1 Speed Up.
• +1.5 Range Up.
• +1 Key, +1 Bomb, +1 Coin.
• One of the twelve zodiac items available in the game.
Type: Passive
Item Pool: Item Room
Cat-O-Nine-Tails
ItemID: 165
"Shot speed up + DMG up"
• +1.0 Damage Up.
• +0.23 Shot Speed Up.
• An item only found in the Boss room pool.
Type: Passive
Item Pool: Boss Room
Celtic Cross
ItemID: 162
"You feel blessed"
• Upon taking damage, you have a chance to gain an invulnerability shield for a few seconds.
• The chance to gain a shield is affected by your luck stat and at +27 Luck it will activate every time.
UNLOCK: Unlock this item by beating the Chest with Maggy.
Type: Passive
Item Pool: Item Room, Angel Room
Ceremonial Robes
ItemID: 216
"Sin up"
• +3 Black Hearts.
• +1 Damage Up.
• When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.
Type: Passive
Item Pool: Devil Room, Curse Room, Demon Beggar
Champion Belt
ItemID: 208
"DMG + Challenge up"
• +1.0 Damage Up.
• Increases the chance of champion enemies appearing.
• An item only found in the Shop room pool.
Type: Passive
Item Pool: Shop
Charm of the Vampire
ItemID: 62
"Kills heal"
• Heals half a heart after every 13 enemies killed.
Type: Passive
Item Pool: Item Room
Chemical Peel
ItemID: 154
"DMG up"
• +2 Damage Up for tears fired from Isaac's left eye.
• If you have an item which modifies which eye you fire tears from, each shot has a 50% chance to do +2 Damage.
Type: Passive
Item Pool: Item Room
Chocolate Milk
ItemID: 69
"Charge shots"
• Isaac can now charge shots for more damage by holding down the fire button.
• At full charge, your tears do 4 times more damage.
• Tears fired at the minimum possible charge do roughly 1/3 of your normal damage.
• Tears up - Spamming the fire button allows for rapid fire shots at normal damage.
Type: Passive, Tear Modifier
Item Pool: Item Room
The Common Cold
ItemID: 103
"Poison damage"
• Tears now have a random chance to apply a poison effect, causing 4 or 6 damage per tick to enemies.
• The chance to fire poison shots is affected by your luck stat and at +12 Luck it will activate every time.
• Gives a big increase in damage to Dr. Fetus bombs.
Type: Passive
Item Pool: Item Room
The Compass
ItemID: 21
"The end is near"
• Shows all icons on the map (e.g. Shop)
• Does not show the layout of the map.
• Room icons will not show if a Curse of the Lost is in effect on the current floor.
Type: Passive
Item Pool: Shop, Beggar
Contract From Below
ItemID: 241
"Wealth, but at what cost?"
• Doubles your pickup drops including chests, soul hearts and all other consumables which spawn at the end of a room.
• Higher chance for 'double trouble' rooms (2 bosses at once).
Type: Passive
Item Pool: Devil Room, Curse Room, Demon Beggar
Converter
ItemID: 296
"Convert your soul"
• When used, converts 2 soul or black hearts into 1 red heart container.
• This item will take from your soul hearts first.
Type: Active
Recharge Time: Instant
Item Pool: Shop
Crack The Sky
ItemID: 160
"Holy white death"
• Creates 5 beams of light from the sky that deal 20 damage to any enemies which come into contact with them.
• The beams now have improved targetting and will attempt to spawn on top of enemies where possible.
Type: Active
Recharge Time: 4 rooms
Item Pool: Item Room
Cricket's Body
ItemID: 224
"Splash damage + tears up"
• -1 Tear Delay (Tears Up).
• -10.0 Range Down.
• Makes tears break into 4 smaller tears on impact with anything which deal half of your damage.
Type: Passive
Item Pool: Item Room
Cricket's Head
ItemID: 4
"DMG up"
• +0.5 Damage Up
• +50% / 1.5 times Damage Multiplier (Does not stack with the Magic Mushroom multipier).
• Tears now have a significant knockback effect (Does not increase the shot speed stat).
• Can be found in golden chests.
• Cricket's Head used to be known as 'Max's Head in the original game and was renamed for Rebirth.
Type: Passive
Item Pool: Item Room, Gold Chest
Crystal Ball
ItemID: 158
"I see my future"
• Upon use, reveals the entire map and gives the player a random tarot card, mystic rune or soul heart.
• Has a chance to drop from playing a fortune machine.
Type: Active
Recharge Time: 6 rooms
Item Pool: Item Room
Cube of Meat
ItemID: 73
"Gotta meat em all"
• An orbital which blocks shots and damages enemies it comes into contact with for 7 damage per tick.
• Exclusively drops from one of the horsemen bosses.
• 2 cubes of meat transform the orbital into a meat head which fires blood tears which deal 3.5 damage each.
• 3 cubes of meat transform it into a meat boy familiar that walks around and deals 3.5 contact damage per tick to enemies.
• 4 cubes of meat cause the meat boy familiar to grow in size and do 5.5 damage per tick instead.
• Any further cubes of meat past 4 will start the cycle again.
UNLOCK: Unlock this item by beating Mom for the first time.
Type: Passive
Item Pool: None (Horsemen boss only)
Cupid's Arrow
ItemID: 48
"Piercing shots"
• Isaac's tears now have a piercing effect which allows them to travel through enemies whilst damaging them.
Type: Passive
Item Pool: Item Room
Cursed Eye
ItemID: 316
"Cursed charged shot"
• Tears are now charged up and fired rapidly in a burst of up to 4 shots at once.
• The amount of tears fired in the charge depends on how long you charge for.
• The eye has three states, white (not firing), black (first second of charging) and blinking between black and white. If you get hit while Cursed eye is a solid black colour you are guaranteed to be teleported to another random room on the floor. If you get hit in either of the other 2 states you will not be teleported.
Type: Passive, Tear Modifier
Item Pool: Item Room, Secret Room
D4
ItemID: 284
"Reroll into something else"
• When used, the D4 re-rolls each item you currently have into another random item from the item room pool.
• Each time an item is generated by the D4, it is also removed from the pool. When the pool is empty, it will eventually re-roll all your items into heart containers.
• Cannot remove Azazel's Brimstone laser.
UNLOCK: Unlock this item by blowing up 30 slot machines.
Type: Active
Recharge Time: 6 rooms
Item Pool: Item Room
D10
ItemID: 285
"Rerolls enemies"
• When used, rerolls all enemies in the room which are currently alive into another random type of enemy from any floor.
• Dangerous to use in early floors, it could replace a basement enemy with something usually found in the Womb only.
• Cannot reroll mini-bosses or bosses.
Type: Active
Recharge Time: 1 room
Item Pool: Item Room
D100
Special item
ItemID: 283
"REEROLLLLL!"
• When used, rerolls each item you currently own into another item room pool item and any pedestal items and pickups in the room.
• Has the combined uses of the D4, D6 and D20.
UNLOCK: Unlock this item by beating Boss Rush with The Lost.
Type: Active
Recharge Time: 6 rooms
Item Pool: Item Room
D20
ItemID: 166
"Reroll the basics"
• Upon use, re-rolls all pickup consumables in the current room into another random kind of pickup.
• This includes hearts, bombs, keys, coins, pills, tarot cards, chests and trinkets.
UNLOCK: Unlock this item by beating the Chest with Isaac.
Type: Active
Recharge Time: 6 rooms
Item Pool: Item Room
The D6
Special item
ItemID: 105
"Reroll your destiny"
• Upon use, any pedestal item (e.g. an item room item) will be re-rolled into another item.
• Isaac starts with this item after it is unlocked.
UNLOCK: Unlock this item by defeating the Isaac boss with Blue Baby.
Type: Active
Recharge Time: 6 rooms
Item Pool: Item Room
Dad's Key
ItemID: 175
"Opens all doors..."
• Upon use, opens all closed doors in the current room, including the ones which require a key to enter and secret room doors.
• Can be used to open the golden door that appears in the Dark Room or the Chest.
UNLOCK: Unlock this item by collecting both Key Pieces #1 & #2 for the first time.
Type: Active
Recharge Time: 2 rooms
Item Pool: Item Room, Key Beggar
Daddy Longlegs
ItemID: 170
"Daddy's love"
• A shadow follows Isaac and stomps on enemies randomly, dealing 40 damage per stomp (2 damage ticks at 20 damage each).
Type: Passive, Familiar
Item Pool: Item Room
Dark Bum
ItemID: 278
"He wants to take your life"
• A familiar beggar similar to Bum Friend that follows Isaac and collects red hearts, giving Isaac soul hearts or spiders in return.
• Soul hearts are the most common payout with only a small chance to spawn friendly or hostile spiders.
• Dark Bum has a small chance to give a black heart instead of a soul heart.
• For every 1.5 red hearts he takes, he will give 1 heart/spider in return.
In Afterbirth this is one of the 3 items required to create the Super Bum familiar transformation.
Type: Passive, Familiar
Item Pool: Item Room, Devil Room
Dark Matter
ItemID: 259
"Fear shot"
• Tears now have a chance to apply the fear effect to enemies, which causes them to run away from Isaac.
• +1.0 Damage Up.
• Reduced tear size.
• The chance to fear enemies is affected by your luck stat and at +20 Luck it will activate every time.
• An item only found in the devil room pool (Note: The Fallen boss pulls items from the Devil Room Pool)
Type: Passive
Item Pool: Devil Room
Dead Bird
ItemID: 117
"Protective buddy"
• When Isaac takes damage, the dead bird will spawn and attack nearby enemies in the current room for 2 damage per tick.
• Eve starts with this item.
Type: Passive, Familiar
Item Pool: Item Room
Dead Cat
ItemID: 81
"9 lives"
• Isaac's health is set to 1 but he also gets 8 extra lives.
• Each time Isaac dies, he will respawn with 1 Health.
• Has a chance to drop from the Super Pride mini boss.
• The floating Dead Cat head that follows you will disappear when you are on your last life (Very useful for The Lost)
• This is one of the items which allows you to transform into Guppy.
Type: Passive
Item Pool: Devil Room, Curse Room, Red Chest, Super Pride Miniboss
Dead Dove
ItemID: 185
"Flight + spectral tears"
• Gives Isaac the ability to fly and spectral tears.
• An item only found in the Angel room.
Type: Passive
Item Pool: Angel Room
Dead Onion
ItemID: 336
"Toxic aura tears"
• Isaac's tears become large, brown and will penetrate all objects and enemies (piercing + spectral).
• -0.25 Range Down.
• -0.4 Shot Speed Down.
• -0.5 Tear Height.
• Despite the increase in tear size, Dead Onion does NOT increase your damage stat.
Type: Passive
Item Pool: Item Room
Dead Sea Scrolls
ItemID: 124
"It's a mystery"
• Upon use, the dead sea scrolls gives a random spacebar item effect.
• An item that can be found in the Angel room.
Type: Active
Recharge Time: 4 rooms
Item Pool: Item Room, Angel Room
Death's Touch
ItemID: 237
"Penetrative shots + DMG up"
• +1.5 Damage Up.
• -0.3 Tears Down.
• Isaac's tears turn into large scythes that penetrate through enemies (Similar to how Death's scythes look).
UNLOCK: Unlock this item by beating Challenge #17 (Waka Waka).
Type: Passive, Tear Modifier
Item Pool: Item Room, Devil Room
Deck of Cards
ItemID: 85
"Reusable card generator"
• Gives Isaac a random tarot card on use.
Type: Active
Recharge Time: 6 rooms
Item Pool: Item Room, Shop
Demon Baby
ItemID: 113
"Auto-turret friend"
• A familiar which follows Isaac and automatically fires tears that deal 3 damage each at any enemies in close range.
UNLOCK: Unlock this item by beating the Dark Room with Azazel.
Type: Passive, Familiar
Item Pool: Item Room, Devil Room
Dessert
ItemID: 24
"HP up"
• +1 Health Up.
Type: Passive
Item Pool: Boss Room, Beggar, Challenge Room
Dinner
ItemID: 23
"HP up"
• +1 Health Up.
Type: Passive
Item Pool: Boss Room, Beggar, Challenge Room
Distant Admiration
ItemID: 57
"Attack fly"
• Gives Isaac an orbiting fly which deals 5 contact damage to enemies per tick.
• Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.
Type: Passive, Orbital
Item Pool: Item Room, Key Beggar
Doctor's Remote
ItemID: 47
"Reusable air strike"
• A target is placed on the floor which can be controlled. After a few seconds a huge missile hits the target and deals 70 damage to anything nearby.
• The damage dealt from this item scales with your damage stat.
• Essentially a one-time more powerful use of the Epic Fetus item.
Type: Active
Recharge Time: 3 rooms
Item Pool: Item Room
A Dollar
ItemID: 18
"$$$"
• +99 coins.
• Can drop from an exploding slot machine while playing it.
Type: Passive
Item Pool: None (Arcade machine only)
Dr. Fetus
Special item
ItemID: 52
"???"
• Instead of tears, Isaac now shoots bombs from his eyes, which explode dealing damage to anything nearby.
• Bomb damage = damage * 5 + 30.
• Tears Down (Tear delay * 2.5).
• Bombs will also synergize with other bomb items and tear modifiers (not including Sad Bombs).
UNLOCK: Unlock this item by beating Mom's Heart 9 times.
In Afterbirth the bomb damage has been greatly increased to dmg * 5 + 30 instead of just dmg * 3.
Type: Passive, Tear Modifier
Item Pool: Item Room
Dry Baby
ItemID: 265
"Immortal friend"
• A familiar that follows Isaac and blocks any shots that hit it.
• If a projectile is blocked by Dry Baby, he has a high chance to activate the Necronomicon effect, dealing 40 damage to the entire room.
• The chance to activate the effect is not changed by your Luck stat.
• Can drop while destroying skulls in the Depths and Necropolis floors.
Type: Passive, Familiar
Item Pool: Item Room
E. Coli
ItemID: 236
"Turdy Touch"
• E. Coli turns normal enemies into poop if they touch you.
• Enemies can turn into poop even if they do not do contact damage, allowing you to apply the effect without taking damage.
• Can be combined with Midas Touch to turn enemies into Golden Poop.
• This does not work on mini-bosses and bosses.
Type: Passive
Item Pool: Item Room
Epic Fetus
Special item
ItemID: 168
"On-demand air strike"
• Tears now become missiles which deal huge damage to anything nearby.
• Missiles damage = damage * 20.
• This item places a controllable red target on the ground which will cause a missile to fall from the sky and hit it after a short period of time.
UNLOCK: Unlock this item by beating Challenge #19 (The Family Man).
Type: Passive, Tear Modifier
Item Pool: Item Room
Eve's Mascara
ItemID: 310
"Shot speed down + DMG up"
• x2 Damage Multiplier.
• Tears Down by exactly half (Tear delay * 2)
• -0.5 Shot Speed Down.
• The tears down from this item is a x2.0 multiplier after the formula, meaning it will always halve your tear rate (Unless you have Monstro's Lung or Soy Milk).
UNLOCK: Unlock this item by beating Boss Rush with Eve.
Type: Passive
Item Pool: Item Room
Experimental Treatment
ItemID: 240
"All stats up! ... and then shuffled"
• When picked up, this item will increase or decrease each one of your stats by a random amount.
• The flavour text for this item is slightly misleading, it is not an all stats up, however will average out as a slight increase overall.
• All 6 stats are affected by this item, including shot speed and luck.
• At least one stat is reduced but no more than 3 stats are reduced.
• Can kill Blue Baby if it removes health, but not other characters.
UNLOCK: Unlock this item by beating Mom's Heart 7 times.
Type: Passive
Item Pool: Item Room, Boss Room, Demon Beggar
Fanny pack
ItemID: 204
"Filled with goodies"
• When Isaac is hit, there is a chance he will drop a pickup (i.e. coin, bomb, key)
Type: Passive
Item Pool: Shop, Beggar
Fate
ItemID: 179
"Flight eternal"
• Gives Isaac an eternal heart and the ability to fly.
• Taking an eternal heart to the next floor or collecting two on the same floor gives you an extra heart container.
UNLOCK: Unlock this item by beating the Chest with Blue Baby.
Type: Passive
Item Pool: Gold Chest
Fire Mind
ItemID: 257
"Flaming tears"
• Isaac's tears now set enemies on fire, leaving a damage over time effect that does 4 or 6 damage per tick.
• There is a chance that tears that hit enemies will explode, leaving a small fire on the floor that damages enemies.
• Exploding tears deal damage * 2 + 22.
• The chance for tears to explode is affected by your luck stat and at +13 Luck it will activate every time.
Type: Passive
Item Pool: Item Room
FLUSH!
ItemID: 291
"..."
• When used, turns every normal enemy in the room into poop!
• Does not work on mini-bosses and bosses.
• Kills poop bosses when used.
Type: Active
Recharge Time: 6 rooms
Item Pool: Item Room
Forever Alone
ItemID: 128
"Attack fly"
• An orbiting fly which deals 2 contact damage per tick to enemies.
• Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.
Type: Passive, Orbital
Item Pool: Item Room
Forget Me Now
ItemID: 127
"I don't remember..."
• Upon use, this item refreshes the current floor with brand new rooms, monsters and items.
UNLOCK: Unlock this item by beating Satan with Blue Baby.
Type: Active
Recharge Time: Instant (One time use)
Item Pool: Item Room, Secret Room
The Gamekid
ItemID: 93
"Temporary Man-Pac"
• When used Isaac transforms into pacman, which makes him invincible and does 40 contact damage to enemies per chomp.
• Everytime you 'eat' an enemy, you regain some health.
UNLOCK: Unlock this item by visiting 10 arcades.
Type: Active
Recharge Time: 6 rooms
Item Pool: Item Room
Gemini
ItemID: 318
"Conjoined friend"
• A familar that is attached to Isaac, which will seek out and damage any enemies close by for 3 contact damage.
• One of the twelve zodiac items available in the game.
Type: Passive, Familiar
Item Pool: Item Room
Ghost Baby
ItemID: 163
"Spectral buddy"
• A familiar which follows Isaac and shoots spectral tears that deal 3.5 damage.
• Ghost Baby fires tears at a rate of 1 tear per second.
• Can drop while destroying skulls in the Depths and Necropolis floors.
Type: Passive, Familiar
Item Pool: Item Room, Devil Room
Gimpy
ItemID: 225
"Sweet suffering"
• When getting hit, this item has a chance to drop a soul heart or black heart.
• When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.
• The chance to spawn a heart is affected by your luck stat and at +22 Luck it will activate 50% of the time.
• Due to a bug, if you have more than 22 luck, Gimpy won't drop any Soul or Black hearts.
• Enemies have a chance to drop half a heart when killed.
Type: Passive
Item Pool: Item Room, Devil Room, Curse Room, Demon Beggar
Gnawed Leaf
ItemID: 210
"Unbreakable"
• If Isaac stands still for a second, he turns to stone, making him invincible until he moves again.
• This item is a reference to the Tanuki suit in Super Mario 3.
Type: Passive
Item Pool: Item Room
Goat Head
ItemID: 215
"He accepts your offering"
• Gives Isaac a guaranteed devil or angel room on every floor they can appear, even if you have already beaten the boss and it didn't show up originally.
• Taking the Goat Head (or any other item) in a Devil Deal significantly lowers your chance for Angel Rooms in the future.
Type: Passive
Item Pool: Devil Room, Curse Room, Red Chest, Golden Chest
GodHead
Special item
ItemID: 331
"God tears"
• Isaac's tears become homing and have a large aura around them, which will deal a lot of damage to anything inside its radius.
• +0.5 Damage Up.
• +1.2 Range Up.
• -0.3 Tears Down.
• -0.3 Shot Speed Down
• +0.8 Tear Height.
UNLOCK: Unlock this item by beating all bosses and completing all post-it note marks in hard mode with The Lost character.
Type: Passive, Tear Modifier
Item Pool: Angel Room
Growth Hormones
ItemID: 70
"DMG up + speed up"
• +1.0 Damage Up
• +0.4 Speed Up
Type: Passive
Item Pool: Boss Room, Demon Beggar
Guardian Angel
ItemID: 112
"Extra protection"
• An orbital which does 7 contact damage per tick, blocks shots and increases the speed of all other orbitals.
UNLOCK: Unlock this item by beating Satan with Maggy.
Type: Passive, Orbital
Item Pool: Angel Room
The Guillotine
ItemID: 206
"An out-of-body experience"
• +1.0 Damage Up.
• -1 Tear Delay (Tears Up).
• Causes Isaac's head to detach and orbit his body, blocking shots and dealing 7 contact damage per tick.
• BFFs will cause the Guillotine head to do double damage (14 damage per tick)
• Tears are still fired from Isaac's head but the hitbox remains around his body.
UNLOCK: Unlock this item by beating the Isaac boss with Judas.
Type: Passive
Item Pool: Item Room
Guppy's Collar
ItemID: 212
"Eternal life?"
• When Isaac dies, he has a 50% chance to respawn with 1/2 a heart.
• This is one of the items which allows you to transform into Guppy.
Type: Passive
Item Pool: Devil Room, Curse Room, Red Chest
Guppy's Hairball
ItemID: 187
"Swing it"
• Follows behind Isaac and can be swung back and forth, dealing 3 contact damage per tick to anything it hits.
• Every time the hairball kills an enemy, it grows in size allowing it to deal more damage.
• This is one of the items which allows you to transform into Guppy.
UNLOCK: Unlock this item by collecting 3 Guppy items and transforming into Guppy.
Type: Passive, Familiar
Item Pool: Devil Room
Guppy's Head
ItemID: 145
"Reusable fly hive"
• When used, spawns between 2-4 blue flies.
• This is one of the items which allows you to transform into Guppy.
• Blue Flies do 2.0x of Isaac's damage.
Type: Active
Recharge Time: 1 room
Item Pool: Devil Room, Curse Room, Red Chest, Gold Chest
Guppy's Paw
ItemID: 133
"Soul converter"
• When used, removes one heart container and gives you 3 soul hearts.
• This is one of the items which allows you to transform into Guppy.
Type: Active
Recharge Time: Instant
Item Pool: Devil Room, Curse Room, Red Chest
Guppy's Tail
ItemID: 134
"Cursed?"
• When picked up, greatly increases your chance of finding chests at the end of a room, while also reducing your chance to find consumables such as keys and bombs.
• This is one of the items which allows you to transform into Guppy.
Type: Passive
Item Pool: Devil Room, Curse Room, Red Chest
Habit
ItemID: 156
"Item martyr"
• When you take damage, this item recharges one room's worth of charge to your spacebar item.
• For example, with the D6 you would need to take damage 6 times to fully recharge it.
Type: Passive
Item Pool: Shop, Angel Room
The Halo
ItemID: 101
"All stats up"
• +1 Health Up.
• +0.3 Damage Up.
• +0.2 Tears Up.
• +0.25 Range Up.
• +0.3 Speed Up.
• +0.5 Tear Height.
UNLOCK: Unlock this item by killing Mom (Mom's Foot or Mom's Heart) using The Bible.
Type: Passive
Item Pool: Item Room, Boss Room, Angel Room
Halo of Flies
ItemID: 10
"Projectile protection"
• Gives Isaac 2 orbital flies which block enemy shots.
• Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.
Type: Passive, Orbital
Item Pool: Item Room, Key Beggar
Harlequin Baby
ItemID: 167
"Double shot buddy"
• A familiar which follows Isaac and shoots two normal tears at once in a V-shaped pattern.
• Each of Harlequin Baby's tears deal 4 damage.
• Harlequin Baby fires tears at a rate of 1 tear per second.
Type: Passive, Familiar
Item Pool: Item Room
Head of Krampus
ItemID: 293
"Krampus rage"
• When used, fires a 4 way brimstone laser in all cardinal directions, dealing a lot of damage to any enemies.
• Maximum potential damage is 462 (20-21 ticks of 22 damage if the laser makes contact the whole duration)
• Laser damage does not scale with your damage stat.
• Has a chance to drop after you beat Krampus.
• If you get close enough to an enemy that has a large hitbox, you can hit it with 2 of the laser beams, allowing you to deal a lot more damage.
UNLOCK: Unlock this item by beating Krampus (Krampus is unlocked by taking 20 devil deal items).
In Afterbirth this item has a 50% chance to rotate like Krampus' spinning attack (25% chance for each direction).
Type: Active
Recharge Time: 6 rooms
Item Pool: None (Krampus only)
Headless Baby
ItemID: 269
"Bloody friend"
• A familiar that follows Isaac and leaves blood creep on the floor as it floats, hurting enemies that walk over it.
Type: Passive, Familiar
Item Pool: Item Room, Devil Room
Hive Mind
ItemID: 248
"Giant spiders and flies"
• Causes your friendly blue spiders and flies to become bigger and do 2x more damage.
• Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.
• Allows Mom's Wig to spawn a maximum of 10 spiders at once instead of 5.
Type: Passive
Item Pool: Shop
Holy Grail
ItemID: 184
"Flight + HP up"
• +1 Health Up
• Gives Isaac the ability to fly.
Type: Passive
Item Pool: Angel Room
Holy Mantle
ItemID: 313
"Holy shield"
• Each time you enter a new room, damage is negated for the first time you get hit.
• Can be used to go in and out of a Curse Room without taking damage.
In Afterbirth The Lost starts with this item after donating 879 coins to the Greed Donation Machine.
Type: Passive
Item Pool: Item Room, Angel Room
Holy Water
ItemID: 178
"Splash!"
• When Isaac takes damage, the bottle breaks and leaves a pool on the floor which deals 8 damage per tick to enemies which walk over it.
Type: Passive, Familiar
Item Pool: Item Room, Angel Room
Hot Bombs
ItemID: 256
"Burning blast +5 bombs"
• +5 Bombs
• Gives all bombs a burning effect when they explode, leaving fire on the floor which deals 22 damage to enemies.
Type: Passive
Item Pool: Item Room
The Hourglass
ItemID: 66
"Temporary enemy slowdown"
• When used, slows down all enemies in the current room and their projectiles for a short period of time.
Type: Active
Recharge Time: 2 rooms
Item Pool: Item Room
How To Jump
ItemID: 282
"It's time you learned how"
• When used, makes Isaac leap in the air, similar to the leaper enemies.
• Maintains momentum if you are already moving in the same direction.
• If you already have an item which gives you flying, this item becomes a dash effect instead.
• Can be used in the Isaac boss fight to jump over the beams of light he spawns.
Type: Active
Recharge Time: Instant
Item Pool: Item Room, Library
Humbleing Bundle
ItemID: 203
"1+1free 4evar!"
• All future pennies, keys, bombs and hearts will drop in pairs.
• Does not work for soul hearts, nickels, dimes, cards or pills.
Type: Passive
Item Pool: Shop
Infamy
ItemID: 242
"Damage reduction"
• Puts a shield on Isaac's face making it so he has a high chance to not take damage to projectiles from any direction.
Type: Passive
Item Pool: Item Room, Gold Chest, Secret Room
Infestation
ItemID: 148
"They grow inside"
• When Isaac gets hit, a few blue flies will randomly spawn.
• Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.
• Blue Flies do 2.0x of Isaac's damage.
Type: Passive
Item Pool: Item Room
Infestation 2
ItemID: 234
"Infestation shot"
• Creates 1-2 friendly spiders when you kill an enemy.
• Spiders are spawned at the location where the enemy died.
Type: Passive
Item Pool: Item Room
The Inner Eye
ItemID: 2
"Triple shot"
• Tears now shoot three at a time (Triple Shot)
• Tears Down significantly (tears = tears * 2.1 + 3).
Type: Passive, Tear Modifier
Item Pool: Item Room
Ipecac
ItemID: 149
"Explosive shots"
• Isaac's tears are replaced with explosive poison bombs, which will arc upwards and explode on contact with the floor, dealing huge damage and leaving a poison effect on enemies in range.
• Ipecac shots are given a flat +40 Damage on top of the normal 3.5 base damage.
• Tears Down (Tear delay * 2 + 10).
• +13.0 Tear Height.
• Shots will damage Isaac if he is in the blast radius when they explode.
UNLOCK: Unlock this item by beating Mom's Heart 6 times.
Type: Passive, Tear Modifier
Item Pool: Item Room
Iron Bar
ItemID: 201
"Concussive tears"
• +0.3 Damage Up.
• Tears now have a chance to concuss enemies, causing them to walk around dazed and confused for a short period of time.
• The chance to concuss enemies is affected by your luck stat and at +27 Luck it will activate every time.
Type: Passive
Item Pool: Item Room
Isaac's Heart
ItemID: 276
"Protect it"
• Prevents Isaac from taking any damage, but instead summons a familiar heart that follows you around. If the heart is hit, Isaac will take damage.
• Sharp Plug becomes useless with this item, due to how damage is prevented on Isaac's body.
UNLOCK: Unlock this item by beating the Isaac boss with The Lost.
Type: Passive, Familiar
Item Pool: Item Room
Isaac's Tears
ItemID: 323
"Collected tears"
• A spacebar item that fires 8 of Isaac's tears in a circle around him.
UNLOCK: Unlock this item by beating the Isaac boss with Isaac.
Type: Active
Recharge Time: 1 bar per tear fired
Item Pool: Item Room
IV Bag
ItemID: 135
"Portable blood bank"
• Upon use, the IV Bag takes half a red heart and spawns some coins (the same effect as a blood donation machine)
• Can drop from a blood donation machine after playing it.
Type: Active
Recharge Time: Instant
Item Pool: None (Blood donation machine only)
The Jar
ItemID: 290
"Save your life"
• Isaac can now pick up hearts while at full health, which will be stored in the Jar and can be spawned again using the spacebar.
• Up to 4 hearts can be stored in The Jar.
• Soul hearts and black hearts cannot be stored.
• If used in a Black heart or Eternal heart super secret room, it will spawn the relevant heart.
Type: Active
Recharge Time: Instant
Item Pool: Shop
Jesus Juice
ItemID: 197
"Damage + range up"
• +0.5 Damage Up.
• +0.25 Range Up.
• +0.5 Tear Height.
Type: Passive
Item Pool: Boss Room
Judas' Shadow
ItemID: 311
"Sweet revenge"
• When you die with this item, you respawn in the previous room as Black Judas with 2 black hearts for health.
• Black Judas has a damage multiplier of 2.00 (double Isaac's damage) and an additional +0.1 Speed.
• Black Judas is considered a separate character by the game, however he can be used to unlock Judas' secrets/achievements.
UNLOCK: Unlock this item by beating Boss Rush with Judas.
Type: Passive
Item Pool: Item Room, Devil Room
Juicy Sack
ItemID: 266
"Sticky babies"
• A familiar that follows isaac around dropping white creep which slows down enemies that walk over it.
• Spawns a familiar blue spider sometimes when you finish a room.
• Blue Spiders do 2.5x of Isaac's damage.
Type: Passive, Familiar
Item Pool: Item Room
Kamikaze
ItemID: 40
"Become the bomb!"
• Causes an explosion near the player which takes away half a heart and does 40 damage all enemies in close proximity.
Type: Active
Recharge Time: Instant
Item Pool: Item Room
Key Piece #1
ItemID: 238
"???"
• Increases your chances to find an Angel Room instead of a Devil Room. See the dedicated Devil room page for more details.
• First half of the key required to enter the door to the Mega Satan boss.
• Drops from one of the angels which appear by bombing the statue in an angel room.
Type: Passive, Familiar
Item Pool: None (Angel statue only)
Key Piece #2
ItemID: 239
"???"
• Increases your chances to find an Angel Room instead of a Devil Room. See the dedicated Devil room page for more details.
• Second half of the key required to enter the door to the Mega Satan boss.
• Drops from one of the angels which appear by bombing the statue in an angel room.
Type: Passive, Familiar
Item Pool: None (Angel statue only)
The Ladder
ItemID: 60
"Building bridges"
• Allows Isaac to walk over gaps with a width of one tile.
Type: Passive
Item Pool: Shop
Lazarus' Rags
ItemID: 332
"Eternal life?"
• Gives Isaac an extra life on death, exactly the same as Lazarus' default respawn effect.
• When you die with this item, you respawn in the same room with 1 heart and the Anemic item.
• The game considers you to be a different character (Lazarus II) when this effect activates.
UNLOCK: Unlock this item by beating the Isaac boss with Lazarus.
Type: Passive
Item Pool: Item Room, Angel Room
Leo
ItemID: 302
"Stompy"
• Isaac gets a lion's mane and now has the ability to crush rocks by walking over them.
• Crushed rocks and poop can fill holes if you walk in their direction.
• Allows you to crush Red Poops and sometimes not take damage. However, If you also have flying you will always take damage.
• One of the twelve zodiac items available in the game.
Type: Passive
Item Pool: Item Room
Latch Key
ItemID: 343
"Luck up"
• +1 Luck Up.
• +1 Soul Heart.
• Spawns 2 keys on the ground.
Type: Passive
Item Pool: Boss Room
Leech
ItemID: 270
"Blood sucker"
• Spawns a familiar leech on the ground that hunts down enemies and heals you for half a heart each time it eats one.
• The Leech deals 1.5 contact damage per tick.
Type: Passive, Familiar
Item Pool: Item Room
Lemon Mishap
ItemID: 56
"Oops..."
• When used, drops a pool of 'lemonade' on the floor which damages any enemies that come into contact with it for 8 damage per tick.
Type: Active
Recharge Time: 2 rooms
Item Pool: Item Room
Libra
ItemID: 304
"You feel balanced"
• Gives you 6 keys, 6 bombs and 6 coins.
• Balances out your stats to bring the high and low stats closer to an average value.
• All future stat upgrading items will now instead spread out across all other stats. For example, an item which usually gives +1 Damage would instead give a small 'all stats up'.
• Stats effected by this item are: Damage, Tears, Range, Speed.
• When taken with another item which gives an extreme value in a certain stat (e.g. Soy Milk) can lead to interesting synergies.
• One of the twelve zodiac items available in the game.
Type: Passive
Item Pool: Item Room
Lil' Brimstone
Special item*
ItemID: 275
"Evil friend"
• A familiar that follows Isaac and can fire up and charge brimstone shots, exactly how the normal Brimstone item works but with less damage.
• A fully charged laser deals 31.5 damage.
• A familiar found in the devil room.
*In Afterbirth this is no longer a Special item!
Type: Passive, Familiar
Item Pool: Item Room, Devil Room
Lil' Haunt
ItemID: 277
"Fear him"
• A familiar ghost that follows Isaac around and chases enemies close-by, damaging them for 2 contact damage and causing a fear effect.
Type: Passive, Familiar
Item Pool: Item Room
Little Baggy
ItemID: 252
"Extra pill room"
• Allows for 2 pills to be held.
• Drops a pill on the floor when picked up.
• All future tarot card drops will now instead become pill drops.
UNLOCK: Unlock this item by picking up 2 of the following items: Roid Rage, The Virus, Growth Hormones, Experimental Treatment or Speed Ball.
Type: Passive
Item Pool: Shop
Little C.H.A.D.
ItemID: 96
"Gives kisses"
• A familiar which follows Isaac and drops half a red heart every 3 rooms.
UNLOCK: Unlock this item by beating the Caves 30 times and defeating C.H.A.D.
Type: Passive, Familiar
Item Pool: Item Room, C.H.A.D. Boss
Little Chubby
ItemID: 88
"Attack buddy"
• A familiar that follows Isaac and charges forwards, dealing 3.5 damage per tick to any enemies it comes into contact with.
UNLOCK: Unlock this item by beating the Caves II for the first time.
Type: Passive, Familiar
Item Pool: Item Room
Little Gish
ItemID: 99
"Sticky friend"
• A familiar that follows Isaac and fires black tar tears, which slow enemy movement and projectile speed for a few seconds.
• Little Gish's tears do 3.5 damage.
• Little Gish fires tears at a rate of 1 tear per second.
• A Guaranteed drop from the Gish boss fight.
UNLOCK: Unlock this item by beating the Depths 20 times and killing the Gish boss.
Type: Passive, Familiar
Item Pool: Item Room, Gish Boss
Little Steven
ItemID: 100
"Psychic friend"
• A familiar that follows Isaac and fires homing tears that deal 3.5 damage each.
• Has a high chance to drop from the Steven boss fight.
• Little Steven fires tears at a rate of 1 tear per second with a slightly longer range than other familiars.
UNLOCK: Unlock this item by killing the Steven boss for the first time.
Type: Passive, Familiar
Item Pool: Item Room, Steven Boss
Loki's Horns
ItemID: 87
"Cross tears"
• Everytime you fire a tear, there is a chance that you will also fire three more tears in all cardinal directions.
• The chance to fire 4-way tears is affected by your luck stat and at +7 Luck it will activate every time.
UNLOCK: Unlock this item by beating Lokii for the first time.
Type: Passive, Tear Modifier
Item Pool: Item Room
Lord of the Pit
ItemID: 82
"Demon wings"
• Gives Isaac demon wings and the ability to fly.
• +0.3 Speed Up (Only applied after the speed stat is next updated).
Type: Passive
Item Pool: Devil Room
Lost Contact
ItemID: 213
"Shielded tears"
• All of Isaac's tears now have a shield, allowing them to block an enemy projectile.
• If a tear blocks something, both Isaac's and the enemies tears are destroyed.
• -0.15 Shot Speed Down.
Type: Passive
Item Pool: Item Room, Secret Room
Lucky Foot
ItemID: 46
"Luck up"
• +1.0 Luck Up.
• Better chance to win while gambling.
• Does not make all pills positive or neutral like the original game.
Type: Passive
Item Pool: Item Room, Beggar
The Ludovico Technique
Special item
ItemID: 329
"Controlled tears"
• You no longer shoot tears and instead now control a single large tear with the arrow keys.
• Items which increase your tears stat will cause the tear to deal damage at a faster rate.
• Items which increase your shot speed cause the tear to travel faster across the screen.
• Ludo and Brimstone create a large controllable red ring of death that does massive damage to anything in its path.
• Taking this with Mom's Knife allows you to remote control the knife around the room, dealing huge damage.
Type: Passive, Tear Modifier
Item Pool: Item Room
A Lump of Coal
ItemID: 132
"My Xmas present"
• Tears gain a damage up and increase in size based on the distance they travel.
• The length of a normal room roughly gives +6 damage, but this can be higher with double rooms or Tiny Planet.
In Afterbirth this item synergises with Brimstone and Tech, allowing them to do more damage the further away the enemy is.
Type: Passive
Item Pool: None (Krampus only)
Lunch
ItemID: 22
"HP up"
• +1 Health Up.
Type: Passive
Item Pool: Boss Room, Challenge Room, Beggar
Maggy's Bow
ItemID: 312
"HP up + you feel healthy"
• +1 Health Up.
• All future red hearts now heal for double. Half hearts heal a whole heart and full hearts heal 2 red hearts.
UNLOCK: Unlock this item by beating Boss Rush with Maggy.
Type: Passive
Item Pool: Item Room
Magic 8 Ball
ItemID: 194
"Shot speed up"
• +0.16 Shot Speed Up.
• Gives Isaac a random tarot card when picked up.
Type: Passive
Item Pool: Boss Room
Magic Fingers
ItemID: 295
"Pay to play"
• Upon use, consumes a coin and deals damage to everything in the room.
• Damage dealt is equal to your tear damage * 2.
Type: Active
Recharge Time: Instant
Item Pool: Item Room, Shop
Magic Mushroom
ItemID: 12
"All stats up!"
• +1 Health Up.
• +0.3 Damage Up.
• +50% / 1.5 times Damage Multiplier (Does not stack with the multipliers from Cricket's Head / Blood of The Martyr+Book of Belial.
• +5.25 Range Up.
• +0.3 Speed Up.
• +0.5 Tear Height.
• Isaac grows in size.
• Similar to the original game, the Magic Mushroom does not give a tears up despite saying 'All Stats Up'.
• Fully restores all red heart containers.
• Can be dropped when exploding mushrooms in the Caves/Catacombs.
Type: Passive
Item Pool: Item Room, Boss Room, Mushrooms
Magic Scab
ItemID: 253
"HP + luck up"
• +1 Health Up.
• +1.0 Luck Up.
Type: Passive
Item Pool: Boss Room
Magneto
ItemID: 53
"Item snatcher"
• Causes pickups on the floor move towards the player.
Type: Passive
Item Pool: Item Room
The Mark
ItemID: 79
"DMG up"
• +1.0 Damage Up.
• +0.2 Speed Up.
• +1 Soul Heart.
Type: Passive
Item Pool: Curse Room, Devil Room
Match Book
ItemID: 344
"Evil up"
• +1 Black Heart
• +3 Bombs
• When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.
Type: Passive
Item Pool: Boss Room
MEAT!
ItemID: 193
"DMG + HP up"
• +1 Health Up.
• +0.3 Damage Up.
Type: Passive
Item Pool: Boss Room
Midas Touch
ItemID: 202
"Golden touch"
• Isaac's touch now petrifies enemies, turning them to gold for a few seconds.
• If an enemy is killed while it is golden, it will drop between 1-4 coins.
• Contact damage is also dealt to enemies equal to the amount of coins Isaac is currently holding.
Type: Passive
Item Pool: Item Room
The Mind
ItemID: 333
"I know all"
• Gives Isaac a full mapping effect, revealing the entire floor and locations of all secret rooms.
UNLOCK: Unlock this item by beating Satan with The Lost.
Type: Passive
Item Pool: Item Room, Angel Room
Mini Mush
ItemID: 71
"Speed + range up"
• +0.3 Speed Up
• Decreases range stat by -4.25 but increases your tear height by 1.5, increasing your actual tear range.
• Causes Isaac to shrink in size.
• Can be dropped when exploding mushrooms in the environment that are usually found in the Caves/Catacombs and in secret rooms.
Type: Passive
Item Pool: Item Room
Missing No.
ItemID: 258
"Syntax error"
• At the start of each floor this item rerolls all your current items, giving you a new item to over-ride each of the one you had.
• A reference to the infamous 'Missingno' glitch from Pokemon.
UNLOCK: Unlock this item by beating Boss Rush with Lazarus.
Type: Passive
Item Pool: Secret Room
Missing Page 2
ItemID: 262
"Evil up + your enemies will pay"
• +1 Black Heart.
• Upon taking damage, if the total sum of Isaac's red hearts + soul hearts is under one and a half hearts, the necronomicon effect will activate, dealing 40 damage to the entire room.
• When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.
Type: Passive
Item Pool: Devil Room, Demon Beggar, Secret Room
Mitre
ItemID: 173
"You feel blessed"
• Gives Isaac a much higher chance to find soul hearts
Type: Passive
Item Pool: Item Room, Angel Room
Mom's Bottle of Pills
ItemID: 102
"Reusable pill generator"
• When used, gives Isaac a random pill.
Type: Active
Recharge Time: 6 rooms
Item Pool: Item Room, Shop, Challenge Room, Beggar, Demon Beggar
Mom's Bra
ItemID: 39
"Mass fear"
• When used, freezes all enemies in the current room temporarily.
Type: Active
Recharge Time: 3 rooms
Item Pool: Item Room, Challenge Room
Mom's Coin Purse
ItemID: 195
"What's all this...?"
• Drops 4 random pills on the floor around Isaac.
Type: Passive
Item Pool: Shop, Boss Room, Challenge Room, Beggar, Demon Beggar
Mom's Contacts
ItemID: 110
"Freeze effect"
• Tears now have a random chance to freeze enemies in place.
• The chance to freeze enemies is affected by your luck stat.
• +0.25 Range Up. (Only applied after the range stat is next updated)
• +0.5 Tear Height. (Only applied after the height stat is next updated)
UNLOCK: Unlock this item by collecting 3 'Mom' items in one playthrough.
Type: Passive
Item Pool: Item Room, Challenge Room
Mom's Eye
ItemID: 55
"Eye in the back of your head"
• Isaac has a random chance to fire another tear out the back of his head.
• The chance to fire the second tear can improve based on your luck stat and will always activate at +2 Luck.
• Synergizes very well with a lot of items. If used with Brimstone you have a 100% chance to fire a laser out the back of your head.
Type: Passive, Tear Modifier
Item Pool: Item Room, Challenge Room
Mom's Eyeshadow
ItemID: 200
"Charm tears"
• Tears have a random chance to charm enemies.
• Charmed enemies will prioritize attacking other enemies in the room, otherwise they will still attack Isaac.
• The chance to charm enemies is affected by your luck stat and at +27 Luck it will activate every time.
Type: Passive
Item Pool: Item Room, Challenge Room
Mom's Heels
ItemID: 30
"Range up"
• +5.25 Range Up
• +0.5 Tear Height.
Type: Passive
Item Pool: Boss Room, Challenge Room
Mom's Key
ItemID: 199
"Less is more now +2 keys"
• +2 Keys
• Higher chance to get more consumable drops from chests.
Type: Passive
Item Pool: Shop, Challenge Room, Key Beggar
Mom's Knife
Special item
ItemID: 114
"Stab stab stab"
• Tears are replaced with a knife which can be charged and thrown in a boomerang style action.
• The knife can also do damage without being thrown as a close range melee weapon.
• When used as a melee weapon, Mom's Knife deals your tear damage * 2 per tick.
UNLOCK: Unlock this item by beating Satan with Isaac.
Type: Passive, Tear Modifier
Item Pool: Item Room, Devil Room, Challenge Room
Mom's Lipstick
ItemID: 31
"Range up"
• +5.25 Range Up
• +0.5 Tear Height.
Type: Passive
Item Pool: Boss Room, Challenge Room
Mom's Pad
ItemID: 41
"Gross..."
• When used, causes all enemies in the current room to run away from Isaac in fear for a few seconds.
Type: Active
Recharge Time: 3 rooms
Item Pool: Item Room, Challenge Room
Mom's Perfume:
ItemID: 228
"Fear shot"
• -1 Tear Delay (Tears Up).
• Isaac's tears have a 15% chance of causing a fear effect.
• Feared enemies will run away from Isaac temporarily.
• The chance to fear enemies is affected by your luck stat and at +85 Luck it will activate every time.
Type: Passive
Item Pool: Item Room, Challenge Room
Mom's Purse
ItemID: 139
"More trinket room"
• Isaac can now hold two trinkets at the same time
• Allows you to pick up more trinkets while also holding The Tick
Type: Passive
Item Pool: Shop
Mom's Wig
ItemID: 217
"You feel itchy"
• Isaac now has a chance to create friendly attack spiders everytime he fires a tear.
• Can create up to a maximum of 5 spiders in the room at one time.
• The Hive Mind item allows Mom's Wig to spawn a maximum of 10 spiders at once instead of 5.
• The chance to create a spider is affected by your luck stat and at +10 Luck it will activate every time.
• Heals you for 1 red heart when picked up.
Type: Passive
Item Pool: Item Room, Challenge Room
Mom's Underwear
ItemID: 29
"Range Up"
• +5.25 Range Up
• +0.5 Tear Height.
Type: Passive
Item Pool: Boss Room, Challenge Room
Money = Power
ItemID: 109
"$$$ = DMG"
• +0.04 Damage Up for every coin you currently have.
• At 99 coins this item gives +3.96 Damage Up.
Type: Passive
Item Pool: Item Room
Mongo Baby
ItemID: 322
"Mongo friend"
• A familiar that will follow Isaac and copy the effect of one of your other familiars.
• If you don't have any other familiars, he will just shoot normal tears.
Type: Passive, Familiar
Item Pool: Item Room
Monster Manual
ItemID: 123
"Temporary buddy generator"
• When used, gives a random familiar for the rest of the room.
Type: Active
Recharge Time: 3 rooms
Item Pool: Item Room
Monstro's Lung
ItemID: 229
"Charged attack"
• Tears can now be charged and released in a shotgun style effect, much like Monstro's main attack.
Type: Passive, Tear Modifier
Item Pool: Item Room
Monstro's Tooth
ItemID: 86
"Summon monstro"
• When used, spawns a Monstro which will jump on a random enemy in the room, dealing 120 damage.
UNLOCK: Unlock this item by beating the Basement II for the first time.
Type: Active
Recharge Time: 3 rooms
Item Pool: Item Room
Mr. Boom
ItemID: 37
"Reusable bomb buddy"
• Drops a large bomb below the player which does 110 damage.
• Has a chance to drop from the Wrath miniboss fight.
Type: Active
Recharge Time: 2 rooms
Item Pool: Item Room, Wrath Miniboss
Mr. Mega
ItemID: 106
"Blast damage"
• +5 Bombs
• Bombs now do 110 damage (+60, up from 50) and have a larger blast radius.
• Can be found in the secret room.
• Has a chance to drop from the Super Wrath miniboss fight.
UNLOCK: Unlock this item by destroying 10 tinted rocks.
Type: Passive
Item Pool: Item Room, Secret Room, Super Wrath Miniboss
The Mulligan
ItemID: 151
"They grow inside"
• Isaac has a 1/6 chance to spawn a blue fly when one of his tears hits an enemy.
• Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.
• Blue Flies do 2.0x of Isaac's damage.
• The chance to activate this effect is not changed with your Luck stat.
Type: Passive
Item Pool: Item Room
Mutant Spider
Special item
ItemID: 153
"Quad Shot"
• Tears now shoot 4 at a time (Quad Shot)
• Tears Down significantly (Tear delay * 2.1 + 3).
Type: Passive, Tear Modifier
Item Pool: Item Room
My Little Unicorn
ItemID: 77
"Temporary badass"
• Gives Isaac temporary invincibility and allows him to do 40 contact damage to enemies per hit.
Type: Active
Recharge Time: 6 rooms
Item Pool: Item Room
My Reflection
ItemID: 5
"Boomerang tears"
• Gives tears a boomerang effect.
• +1.5 Range Up.
• +0.6 Shot Speed Up.
• +1 Tear Height.
Type: Passive, Tear Modifier
Item Pool: Item Room
Mysterious Liquid
ItemID: 317
"Toxic splash damage"
• When Isaac's tears hit anything, they leave a green toxic creep on the floor that damages enemies.
Type: Passive
Item Pool: Item Room
Mystery Sack
ItemID: 271
"?"
• A bag that follows Isaac and drops a random pickup every few rooms (Fixed in patch v1.04).
• Can drop any kind of heart, coin, bomb or key.
UNLOCK: Unlock this item by beating the Dark Room with Eden.
Type: Passive, Familiar
Item Pool: Item Room, Beggar, Secret Room
The Nail
ItemID: 83
"Temporary demon form"
• +0.7 Damage Up.
• -0.18 Speed Down.
• +1 Soul Heart
• Gives you the ability to crush rocks by walking over them.
• All the above effects are only active when the item is used.
UNLOCK: Unlock this item by beating the Boss Rush with Azazel.
Type: Active
Recharge Time: 6 rooms
Item Pool: Devil Room
The Necronomicon
ItemID: 35
"Mass room damage"
• Deals 40 damage to everything in the room when used.
UNLOCK: Unlock this item by using 4 Death Cards.
Type: Active
Recharge Time: 6 rooms
Item Pool: Library, Secret Room, Devil Room
The Negative
ItemID: 328
"Fate chosen"
• Damages all enemies in the room for 40 damage when hit down to 1/2 heart remaining.
• Gives you access to the Dark Room floor.
• When unlocked, is guaranteed to drop after the Mom's Foot boss fight.
UNLOCK: Unlock this item by beating Satan in Sheol 5 times.
Type: Passive
Item Pool: None (Mom's foot boss only)
Notched Axe
ItemID: 147
"Rocks didn't stand a chance"
• Each charge of this item allows Isaac to break all rocks, pots and secret room doors in the current room.
• Cannot break the stone blocks which appear in the environment.
• If Isaac is damaged while the effect is active, it will deactivate.
Type: Active
Recharge Time: 3 rooms
Item Pool: Item Room
Number One
ItemID: 6
"Tears up"
• Gives you a very high tear rate in exchange for a big range down.
• +1.5 Tears Up.
• -15.78 Range Down.
• +0.45 Tear Height.
Type: Passive
Item Pool: Item Room
Odd Mushroom (Thick)
ItemID: 121
"DMG up"
• +1 Health Up.
• +0.3 Damage Up.
• +0.25 Range Up.
• -0.1 Speed Down.
• +0.5 Tear Height.
Type: Passive
Item Pool: Item Room, Secret Room
Odd Mushroom (Thin)
ItemID: 120
"Fire rate up"
• Gives you a high rate of fire in exchange for a damage down.
• +1.7 Tears Up.
• +0.3 Speed Up.
• Damage Down (damage * 0.9 - 0.4).
Type: Passive
Item Pool: Item Room, Secret Room
Old Bandage
ItemID: 219
"HP up"
• +1 Health Up.
• The given heart container is empty.
• When you get hit, you will sometimes cause hearts to drop on the floor.
Type: Passive
Item Pool: Boss Room
Ouija Board
ItemID: 115
"Spectral tears"
• Gives Isaac spectral tears which allows them to travel through objects in the environment (i.e. rocks).
Type: Passive
Item Pool: Item Room
The Pact
ItemID: 80
"DMG + tears up"
• +0.5 Damage Up.
• +0.7 Tears Up.
• +2 Soul Hearts.
Type: Passive
Item Pool: Devil Room, Curse Room
Pageant Boy
ItemID: 141
"Ultimate grand supreme"
• Spawns 7 random coins around Isaac on the floor.
• Isaac wears a pink crown on his head.
Type: Passive
Item Pool: Boss Room
Pandora's Box
ItemID: 297
"? ?"
• When used, this item will spawn a set of items or consumables based on which floor you are currently on.
• Basement 1: 2 Soul hearts. Basement 2: 2 Bombs + 2 Keys.
• Caves 1: 1 Boss Item. Caves 2: 1 Boss Item + 2 Soul Hearts.
• Depths 1: 4 Soul hearts. Depths 2: 20 coins.
• Womb 1: 2 Boss Items. Womb 2: Bible.
• Sheol: 1 Devil Room Item + 1 Black Heart. Cathedral: 1 Angel Room Item + 1 Eternal Heart.
• Chest: 1 coin. Dark Room: Nothing!
• Pandora's Box considers XL floors to always be the first floor of a chapter.
UNLOCK: Unlock this item by beating the Dark Room with Lazarus.
Type: Active
Recharge Time: One time use
Item Pool: Shop, Red Chest
The Parasite
ItemID: 104
"Split shot"
• Isaac's tears now split into two upon contact with enemies or the environment.
• Tears that split off from the main tear do less damage (tear damage * 0.25).
UNLOCK: Unlock this item by collecting two of the following items: Bob's Rotten Head, Dead Cat, Cricket's Head, Tammy's Head.
Type: Passive
Item Pool: Item Room
The Peeper
ItemID: 155
"Plop!"
• Gives Isaac an eye companion that floats around the room and deals 8 damage per tick on contact with enemies.
Type: Passive, Familiar
Item Pool: Item Room
Pentagram
ItemID: 51
"DMG up"
• +1.0 Damage Up.
• Higher chance of a Devil Deal opening after the boss fight (Approximately +20% through testing).
Type: Passive
Item Pool: Boss Room, Curse Room, Devil Room
PhD
ItemID: 75
"Better pills"
• All pills now have a positive or neutral effect.
• Pills are identified before using them.
• Drops one pill on pickup.
• Heals for 2 full red hearts.
Type: Passive
Item Pool: Item Room, Shop
Piggy Bank
ItemID: 227
"My life savings"
• +3 Coins when picked up.
• When you take damage, 1 or 2 coins will drop on the floor.
Type: Passive
Item Pool: Item Room, Shop
Pisces
ItemID: 309
"Tears up + knockback shot"
• -1 Tear Delay (Tears Up).
• Tears now have a knockback effect, which pushes enemies backwards.
• One of the twelve zodiac items available in the game.
Type: Passive
Item Pool: Item Room
Placenta
ItemID: 218
"HP up + regen"
• +1 Health Up.
• Gives the player health regeneration over time.
Type: Passive
Item Pool: Boss Room
Pinking Shears
ItemID: 107
"Cut and run"
• Cuts Isaac's head from his body for the current room, allowing him to fly and leaving the decapitated body to run around attacking enemies for 5.5 damage per tick.
Type: Active
Recharge Time: 6 rooms
Item Pool: Item Room
The Polaroid
ItemID: 327
"Fate chosen"
• Gives Isaac an invincibility shield for a few seconds when hit down to 1/2 heart remaining.
• Gives you access to the Chest floor.
• When unlocked, is guaranteed to drop after the Mom's Foot boss fight.
UNLOCK: Unlock this item by beating Isaac in the Cathedral 5 times.
Type: Passive
Item Pool: None (Mom's foot boss only)
Polyphemus
Special item
ItemID: 169
"Mega tears"
• High Damage Up - 2 * (damage + 4).
• Tears Down significantly (Tear delay * 2.1 + 3).
• If a tear kills an enemy, it continues to travel forward with the leftover damage.
Type: Passive
Item Pool: Item Room
A Pony
ItemID: 130
"Flight + dash attack"
• Allows Isaac to fly while the Pony is held.
• Sets your speed stat to 1.5 if it isn't already that high.
• When the active attack is used, Isaac will dash across the screen dealing 40 contact damage to anything he hits.
• Drops from the Headless Horseman boss fight.
Type: Active
Recharge Time: 6 rooms
Item Pool: None (Headless horseman only)
The Poop
ItemID: 36
"Plop!"
• Drops a poop on the floor.
• Blue Baby starts with this item.
• Can be placed next to a pit and exploded to make a bridge.
• Can be placed over a broken red poop to overwrite it, causing it to no longer regenerate.
Type: Active
Recharge Time: 1 room
Item Pool: Item Room
Portable Slot
ItemID: 177
"Gamble 24/7"
• Using the portable slot takes a coin and has a chance to give a pickup - Exactly the same as how the normal slot machines work.
Type: Active
Recharge Time: Instant
Item Pool: Shop, Beggar
Prayer Card
ItemID: 146
"Reusable eternity"
• Gives Isaac an eternal heart when used.
• Taking an eternal heart to the next floor or collecting two on the same floor gives you an extra heart container.
Type: Active
Recharge Time: 6 rooms
Item Pool: Item Room, Angel Room
Proptosis
ItemID: 261
"Short range mega tears"
• Gives Isaac high damage tears with a short range.
• Tear size and damage falls off very fast with this item, the further the tear travels the less damage it does.
• Tear damage starts at double (+100%) and decreases over range to roughly (+30%).
• Despite the very small tears visually, Proptosis is always a damage up at any range for tears. However with lasers such as Brimstone this point is no longer true.
Type: Passive, Tear Modifier
Item Pool: Item Room
Punching Bag
ItemID: 281
"Scape goat"
• Spawns a friendly Mulligan that walks around the room. Mulligan can be hit by enemy projectiles, making him a good shield.
• Enemies will sometimes target the Mulligan if he is closer.
Type: Passive, Familiar
Item Pool: Item Room
Pyro
ItemID: 190
"99 bombs"
• +99 Bombs.
Type: Passive
Item Pool: Item Room, Secret Room
Pyromaniac
Special item
ItemID: 223
"Hurts so good +5 bombs"
• +5 Bombs
• All explosions now heal Isaac for 1 heart instead of hurting him.
• Isaac will also be healed by other sources such as Mom's leg stomp, Satan's leg stomp.
Type: Passive
Item Pool: Item Room
A Quarter
ItemID: 74
"+25 coins"
• +25 Coins
• Has a very small chance to drop after destroying one of the pots that appear in the Basement and Cellar floors.
• Has a chance to drop from the Super Greed miniboss fight.
UNLOCK: Unlock this item by beating Mom's Heart 8 times.
Type: Passive
Item Pool: Item Room, Secret Room, Super Greed Miniboss
Rainbow Baby
ItemID: 174
"Random buddy"
• A familiar the follows Isaac and fires random tears.
• Rainbow Baby's tears can choose from any of the other familiars, such as homing, spectral, tar shots etc.
Type: Passive, Familiar
Item Pool: Item Room
Raw Liver
ItemID: 16
"HP up"
• +2 Health Up.
• Full red heart heal.
Type: Passive
Item Pool: Secret Room
Razor Blade
ItemID: 126
"Feel my pain"
• When used, deals damage to Isaac in exchange for +1.2 damage up which lasts for the current room.
UNLOCK: Unlock this item by beating Satan with Eve.
In Afterbirth Eve starts with this item after donating 439 coins to the Greed Donation Machine.
Type: Active
Recharge Time: Instant
Item Pool: Devil Room
Red Candle
ItemID: 289
"Flame on"
• Allows you to fire a red flame infront of you, similar to the Blue Candle item, however the flame will stay for the current room.
• Each flame deals 125 total damage.
• The flame will shrink in size when deals damage to something and eventually disappear.
UNLOCK: Unlock this item by donating 400 pennies to the Shop.
Type: Active
Recharge Time: Timed (A few seconds)
Item Pool: Shop
The Relic
ItemID: 98
"Soul generator"
• A blue cross that follows Isaac and drops a soul heart every 4 rooms.
UNLOCK: Unlock this item by beating the Isaac boss with Maggy.
Type: Passive, Familiar
Item Pool: Item Room, Angel Room
Remote Detonator
ItemID: 137
"Remote bomb detonation"
• +5 Bombs.
• Bombs no longer automatically explode and will only do so when you activate the remote detonator.
• Can be used to detonate Dr. Fetus bombs early.
Type: Active
Recharge Time: Instant
Item Pool: Item Room, Shop
Robo-Baby
ItemID: 95
"Friends till the bzzzttt"
• A familiar which follows Isaac and shoots lasers, similar to the Technology item.
• Robo-Baby's laser is spectral and piercing (It will pass through rocks and objects in the environment)
• Robo-Baby's lasers deal 3.5 damage per hit.
Type: Passive, Familiar
Item Pool: Item Room
Robo-Baby 2.0
ItemID: 267
"We worked out all the kinks"
• A familiar that is controlled via the arrow keys and will automatically fire a laser if anything is in its line of sight.
• Robo-Baby 2.0's lasers deal 3.5 damage per hit.
UNLOCK: Unlock this item by beating Challenge #16 (Computer Savvy).
Type: Passive, Familiar
Item Pool: Item Room
Roid Rage
ItemID: 14
"Speed and range up"
• +0.6 Speed Up.
• +5.25 Range Up.
• +0.5 Shot Height.
Type: Passive
Item Pool: Item Room, Boss Room, Demon Beggar
Rosary
ItemID: 72
"Faith up"
• +3 Soul Hearts.
• Adds several instances of The Bible item into the Boss Room, Shop, Beggar, Secret Room, Gold Chest and Devil Pools.
Type: Passive
Item Pool: Item Room, Angel Room
Rotten Baby
ItemID: 268
"Infested friend"
• A familiar which follows Isaac and spawns a blue flies.
• Rotten Baby can only create one fly at a time, meaning if he has created a fly he cannot make another until it is used.
• Blue Flies do 2.0x of Isaac's damage.
• The Hive Mind item will cause Rotten Baby's flies to deal double damage.
Type: Passive, Familiar
Item Pool: Item Room, Devil Room
Rotten Meat
ItemID: 26
"HP up"
• +1 Health Up
Type: Passive
Item Pool: Boss Room, Beggar, Challenge Room
Rubber Cement
ItemID: 221
"Bouncing tears"
• Isaac's tears now bounce off walls and objects in the environment, such as rocks and pots.
• Allows tears to hit the same enemy multiple times.
• If you also have Lost Contact, tears will bounce off enemy projectiles instead of being destroyed.
UNLOCK: Unlock this item by beating Mom's heart 2 times.
Type: Passive
Item Pool: Item Room
Sack of Pennies
ItemID: 94
"Gives money"
• A bag that floats around following Isaac and drops a random coin every 2 rooms.
UNLOCK: Unlock this item by beating Isaac with Cain.
Type: Passive, Familiar
Item Pool: Item Room, Secret Room
Sacred Heart
Special item
ItemID: 182
"Homing shots + DMG up"
• Tears are now white, do a lot more damage and move slower across the screen with a homing effect.
• Health Up.
• Damage Up (damage * 2.3 + 1).
• -0.4 Tears Down.
• -0.25 Shot Speed Down.
• +0.375 Range Up.
• +0.75 Tear Height.
• Full red heart heal.
Type: Passive, Tear Modifier
Item Pool: Angel Room
Sacrificial Dagger
ItemID: 172
"My fate protects me"
• Gives Isaac an orbital knife that does 15 damage per tick on contact with enemies.
• The Sacrificial Dagger DOES block shots in Rebirth, unlike the original game.
• Synergises very well with invulnerability items such as Book of Shadows.
UNLOCK: Unlock this item by beating the Chest with Eve.
Type: Passive, Orbital
Item Pool: Item Room, Devil Room
Sad Bombs
ItemID: 220
"Tear blast +5 bombs"
• +5 Bombs
• Everytime a bomb explodes, it will release a circle of tears outwards, much like the Tammy's Head effect.
• The tears from each bomb are affected by any tear modifiers Isaac has on his own tears.
• The tears caused by Sad Bombs are much larger and do a lot more damage than Isaac's normal tears.
Type: Passive
Item Pool: Item Room
The Sad Onion
ItemID: 1
"Tears up"
• +0.7 Tears Up
Type: Passive
Item Pool: Item Room
Safety Pin
ItemID: 339
"Evil up + range + shot speed"
• +5.25 Range Up.
• +0.16 Shot Speed Up.
• +1 Black Heart.
• +0.5 Tear Height.
• When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.
Type: Passive
Item Pool: Boss Room
Sagittarius
ItemID: 306
"Penetrative shot + speed up"
• +0.2 Speed Up.
• Tears now turn into arrow heads and pierce through enemies.
• Tears do not travel through rocks with this item.
• One of the twelve zodiac items available in the game.
Type: Passive
Item Pool: Item Room
Samson's Chains
ItemID: 321
"The ol' ball and chain"
• An iron ball and chain attached to Isaac, similar to Guppy's Hairball that you can fling around to deal 5 damage per tick.
• The ball will block enemy shots and can also destroy environmental objects such as rocks, mushrooms and skulls.
• Does not decrease your movement speed stat at all however the ball has to be dragged around causing Isaac to slow down slightly when the chain is fully extended.
UNLOCK: Unlock this item by beating Boss Rush with Samson.
Type: Passive, Familiar
Item Pool: Item Room, Secret Room
The Satanic Bible
ItemID: 292
"Reusable evil"
• When used, gives Isaac +1 Black Heart.
• When depleted, Black Hearts deal 40 damage to the entire room, in a Necronomicon style effect.
UNLOCK: Unlock this item by beating the Isaac boss with Azazel.
Type: Active
Recharge Time: 6 rooms
Item Pool: Item Room, Library, Devil Room
Scapular
ItemID: 142
"You have been blessed"
• Once per room when you are damaged down to half a heart, you gain 1 soul heart.
Type: Passive
Item Pool: Item Room, Angel Room
Scissors
ItemID: 325
"Lose your head"
• Similar to the Pinking Shears, when used will cut your head from your body, however this item allows you to control Isaac's body.
• Isaac's detached head will remain stationary and shoot tears in the direction you are firing.
UNLOCK: Unlock this item by dying 100 times.
Type: Active
Recharge Time: 2 rooms
Item Pool: Item Room
Scorpio
ItemID: 305
"Poison tears"
• Isaac's tears turn bright green and always apply a poison effect to enemies which deals 4 or 6 damage per tick.
• This is essentially a superior version of The Common Cold item.
• Gives Dr. Fetus bombs a big increase in damage.
• One of the twelve zodiac items available in the game.
Type: Passive
Item Pool: Item Room
Screw
ItemID: 255
"Tears + shot speed up"
• +0.5 Tears Up
• +0.2 Shot Speed Up
Type: Passive
Item Pool: Boss Room
Sharp plug
ItemID: 205
"Charge with blood"
• When your spacebar item is out of charge, you can press spacebar to use it at the cost of 2 health.
• This item only costs 1/2 a heart to use if you have The Wafer or the Cancer item.
• The Sharp Plug will take health from Soul/Black hearts (if any) before taking red hearts.
Type: Passive
Item Pool: Shop
Shoop Da Whoop
ItemID: 49
"BLLLARRRRGGG!"
• When used, fires a high damage laser in a straight line across the room in a similar way to Brimstone.
• The laser deals damage equal to your tear damage * 4, at 7 ticks per laser, meaning the maximum potential damage per laser is your tear damage * 28.
• Has a chance to drop from the Envy and Super Envy miniboss fights.
Type: Active
Recharge Time: 2 rooms
Item Pool: Item Room, Envy Miniboss, Super Envy Miniboss
Sissy Long Legs
ItemID: 280
"She loves you"
• An adorable friendly blue spider that walks around the room laying other blue spiders which attack enemies.
• Blue Spiders do 2.5x of Isaac's damage.
• She can only spawn a maximum of up to 5 spiders at a time and will only do so while there are enemies in the room.
Type: Passive, Familiar
Item Pool: Item Room
Sister Maggy
ItemID: 67
"Friends 'till the end"
• A familiar which follows Isaac around and shoots blood tears that deal 3.5 damage.
• The tears appear red but have no additional damage.
• Sister Maggy fires tears at a rate of 1 tear per second.
Type: Passive, Familiar
Item Pool: Item Room, Devil Room
Skatole
ItemID: 9
"Fly love"
• All fly enemies are no longer aggressive towards Isaac.
• Is only available from the shell game in the arcade.
• Can be won from the arcade skull game.
• Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.
Type: Passive
Item Pool: None (Arcade shell game only)
Skeleton Key
ItemID: 17
"99 keys"
• +99 Keys
Type: Passive
Item Pool: Secret Room
The Small Rock
ItemID: 90
"DMG up"
• +1.0 Damage Up.
• +0.2 Tears Up. (Only applied after the tears stat is next updated)
• -0.2 Speed Down. (Only applied after the speed stat is next updated)
• Has a chance to drop when exploding a tinted rock.
UNLOCK: Unlock this item by destroying 100 tinted rocks.
Type: Passive
Item Pool: None (Tinted rock only)
Smart Fly
ItemID: 264
"Revenge fly"
• A yellow orbital fly that will block shots and when Isaac gets hit, will seek out the nearest enemy and attack it.
• If the fly is in its attacking state and there are no longer any enemies in range, it will return to Isaac and go back to being a defensive orbital.
• Picking up this item as well as 2 other fly-type items will allow you to transform into Lord of the Flies.
Type: Passive, Familiar
Item Pool: Item Room, Key Beggar
SMB Super Fan
ItemID: 189
"All stats up"
• Isaac turns red like Meatboy.
• +1 Health Up.
• +0.3 Damage Up.
• +0.2 Tears Up.
• +0.5 Range Up.
• +0.2 Speed Up.
• +1.0 Tear Height.
• Full red heart heal.
UNLOCK: Unlock this item by beating Challenge #14 (It's in the Cards).
Type: Passive
Item Pool: Item Room
A Snack
ItemID: 346
"HP up"
• +1 Health Up.
Type: Passive
Item Pool: Boss Room
The Soul
ItemID: 335
"I am all"
• +2 Soul Hearts.
• Enemy projectiles will now slowly curve away from Isaac and avoid hitting him.
UNLOCK: Unlock this item by beating Dark Room with The Lost.
Type: Passive
Item Pool: Item Room, Angel Room
Soy Milk
Special item*
ItemID: 330
"DMG down + tears way up"
• Very high Tears Up: (delay /4) - 2
• -80% Damage Down.
*In Afterbirth this is no longer a Special item!
Type: Passive, Tear Modifier
Item Pool: Item Room
Speed Ball
ItemID: 143
"Speed + shot speed up"
• +0.3 Speed Up.
• +0.2 Shot Speed Up.
Type: Passive
Item Pool: Item Room, Boss Room, Demon Beggar
Spelunker Hat
ItemID: 91
"See-through doors"
• Reveals the location of the Secret Room and Super Secret Room when you are in a room directly next to them.
Type: Passive
Item Pool: Item Room
Spider Butt
ItemID: 171
"Mass enemy slowdown + damage"
• Upon use, does 10 damage to all enemies in the room and gives them a slowing effect.
Type: Active
Recharge Time: 2 rooms
Item Pool: Item Room
Spider Bite
ItemID: 89
"Slow effect"
• Tears now have a chance of slowing enemies and their projectiles for 2.5 seconds.
• The chance to slow enemies is affected by your luck stat and at +15 Luck it will activate every time.
Type: Passive
Item Pool: Item Room
Spiderbaby
ItemID: 211
"Spider revenge"
• Creates friendly attack spiders when Isaac is damaged.
Type: Passive
Item Pool: Item Room
Spirit of the Night
ItemID: 159
"Scary"
• Gives Isaac the ability to fly and spectral tears.
Type: Passive
Item Pool: Devil Room
Spoon Bender
ItemID: 3
"Homing shots"
• Gives Isaac's tears a homing effect.
Type: Passive
Item Pool: Item Room
Squeezy
ItemID: 196
"Tears up"
• +2 Soul Hearts.
• +0.4 Tears Up.
Type: Passive
Item Pool: Boss Room
Starter Deck
ItemID: 251
"Extra card room"
• Isaac can now hold 2 tarot cards at once.
• All future pill drops (including Mom's Coin Purse) will now instead become Tarot card drops.
• An item only available in the Shop room.
Type: Passive
Item Pool: Shop
Steam Sale
ItemID: 64
"50% off"
• Items in the shop are now -50% off, rounded down to the nearest whole number.
• Has a chance to drop from the Greed miniboss fight or when bombing the shopkeeper.
Type: Passive
Item Pool: Shop, Greed Miniboss, Shopkeeper
Stem Cells
ItemID: 176
"HP up"
• +1 Health Up.
• +0.16 Shot Speed Up.
Type: Passive
Item Pool: Item Room, Boss Room
Steven
ItemID: 50
"DMG up"
• +1 Damage Up.
• Has a small chance to drop from the Steven boss fight.
UNLOCK: Unlock this item by beating the Basement 40 times and defeating the Steven boss.
In Afterbirth this item also appears in the Gold Chest item pool.
Type: Passive
Item Pool: None (Steven boss only)
Stigmata
ItemID: 138
"DMG + HP up"
• +1 Health Up.
• +0.3 Damage Up.
Type: Passive
Item Pool: Item Room
Stop Watch
Special item
ItemID: 232
"Let's slow this down a bit"
• +0.3 Speed Up.
• After you get hit the Stop Watch applies a slowing effect for the rest of the room to all enemies and their projectiles.
• The effect will still activate when hit while the Holy Mantle effect is active.
• The slowing effect has a reduced effect against Brimstone lasers fired by enemies.
UNLOCK: Unlock this item by donating 999 pennies to the Shop.
In Afterbirth this is no longer a Special Item and the slowing effect only activates for one room after taking damage.
Type: Passive
Item Pool: Shop
Strange Attractor
ItemID: 315
"Magnetic tears"
• Enemies and pickups (keys, bombs etc.) are now magnetically attracted to Isaac's tears.
• Can cause some enemies to have unpredictable movement.
Type: Passive
Item Pool: Item Room
Super Bandage
ItemID: 92
"+2 hearts"
• +1 Health Up.
• +2 Soul Hearts
UNLOCK: Unlock this item by making a Super Bandage Girl.
Type: Passive
Item Pool: Item Room, Boss Room
Synthoil
ItemID: 345
"DMG up + range"
• +1.0 Damage Up.
• +5.25 Range Up.
• +0.5 Tear Height.
Type: Passive
Item Pool: Boss Room
Tammy's Head
ItemID: 38
"Reusable tear burst"
• Fires 10 tears in a circle around Isaac.
• Each tear is equal to your damage stat + 25 flat damage.
• The tears spawned from Tammy's Head retain tear effects of Isaac's tears, such as poison or homing.
• Synergizes extremely well with Brimstone due to how the damage from both items is calculated when combined.
Type: Active
Recharge Time: 1 room
Item Pool: Gold Chest
Taurus
ItemID: 299
"Speed down + rage is building"
• -0.3 Speed Down.
• While in a hostile room your speed raises at a rate of +0.065 per second.
• When you hit a speed stat of 2.0, Isaac will gain the My Little Unicorn invincibility effect for a few seconds, increasing speed and allowing him to run into enemies to deal 40 contact damage per hit.
• The time it takes for the effect to activate becomes shorter with a higher base Speed stat.
• One of the twelve zodiac items available in the game.
Type: Passive
Item Pool: Item Room
Tech.5
ItemID: 244
"It's still being tested"
• Gives Isaac a laser which is positioned in the centre of his head and will fire at random intervals while firing tears.
• Each laser does damage equal to your current tear damage.
• The laser will occasionally fire with one of these effects: Hook Worm, Spoon Bender or Tiny Planet.
• Luck has no effect on the rate at which Tech.5 fires and does not scale with items that increase your tears stat.
UNLOCK: Unlock this item by beating Challenge #18 (The Host).
Type: Passive, Tear Modifier
Item Pool: Item Room
Technology
ItemID: 68
"Laser tears"
• Isaac's tears are replaced with a laser that has unlimited range and can only fire at right angles.
• Lasers travel through enemies but not obstacles in the room.
Type: Passive, Tear Modifier
Item Pool: Item Room
Technology 2
ItemID: 152
"Laser"
• Isaac now also has a laser with unlimited range which fires continuously and does damage very rapidly.
• -35% Damage Down (0.65 damage multiplier).
Type: Passive, Tear Modifier
Item Pool: Item Room
Telepathy for Dummies
ItemID: 192
"Temporary psychic shot"
• When used, Isaac gains homing shots for the current room.
Type: Active
Recharge Time: 2 rooms
Item Pool: Item Room, Library
Teleport
ItemID: 44
"Teleport!"
• Teleports Isaac to a random location on the map.
Type: Active
Recharge Time: 2 rooms
Item Pool: Item Room
There's Options
ItemID: 249
"More options"
• Two items now spawn after beating a boss fight and the boss rush, however only one can be taken and the other will disappear.
• The additional item will always pick from the Boss Item Pool.
• Appears in the shop item pool.
• Does nothing after the Krampus fight.
• Unlocked by donating to the donation machine in the shop.
UNLOCK: Unlock this item by donating 50 pennies to the Shop.
Type: Passive
Item Pool: Shop
Thunder Thighs
ItemID: 314
"HP + speed down + you feel strong"
• +1 Health Up.
• -0.4 Speed Down.
• You can now break obstacles by walking over them.
• Holes in the ground can be filled by crushing adjacent rocks, similar to how this can be done with bombs.
• Allows you to crush Red Poops and sometimes not take damage. However, If you also have flying you will always take damage.
Type: Passive
Item Pool: Item Room
Tiny Planet
ItemID: 233
"Orbiting tears + range up"
• +7.0 Tear Height.
• Tears now revolve around Isaac's Body at a fixed distance until they hit the ground.
• Aiming in the opposite direction is often better due to how the tears circle around Isaac.
• Causes a lot of great synergies with items such as Lump of Coal, Brimstone, Rubber Cement, Technology and most of the worm trinkets.
Type: Passive, Tear Modifier
Item Pool: Item Room
Toothpicks
ItemID: 183
"Tears + shot speed up"
• +0.7 Tears Up.
• +0.16 Shot Speed Up.
• Does not increase your damage, simply makes your tears red.
Type: Passive
Item Pool: Boss Room
Torn Photo
ItemID: 341
"Tears + shot speed up"
• +0.7 Tears Up.
• +0.16 Shot Speed Up.
Type: Passive
Item Pool: Boss Room
Tough Love
ItemID: 150
"Tooth shot"
• Isaac has a random chance to fire a tooth shot instead of a tear sometimes.
• Teeth shots deal damage equal to your tear damage * 3.2.
• The chance to fire a tooth is affected by your luck stat and at +9 Luck it will activate every time.
• Synergizes well with some tear modifiers such as Ipecac, which causes it to do massive damage.
Type: Passive
Item Pool: Item Room
Transcendence
ItemID: 20
"We all float down here..."
• Gives Isaac the ability to fly.
UNLOCK: Unlock this item by beating Mom's Heart 3 times.
Type: Passive
Item Pool: Secret Room
Treasure Map
ItemID: 54
"Full visible map"
• Reveals the entire map for every floor not including both secret room locations.
• Does not show the icons for any unknown rooms.
• Can still help you to guess which direction the boss room is in, due to the fact that the Boss Room is usually in the room furthest away from the first room.
Type: Passive
Item Pool: Shop, Beggar
Trinity Shield
ItemID: 243
"You feel guarded"
• Puts a shield in front of Isaac which blocks projectiles.
• The shield will rotate based on the direction in which Isaac is firing tears.
Type: Passive
Item Pool: Angel Room
Undefined
ItemID: 324
"Undefined"
• Upon use, teleports you to one of the following rooms at random: Item room, Secret room, Super secret room, the I AM ERROR room or the Black Market (very low chance).
• Allows you to loop through and the final floor infinitely. If you can get Undefined to teleport you to an I AM ERROR room, there will be a beam of light that takes you back to a new Chest/Dark Room floor with the same layout and refreshed rooms.
UNLOCK: Unlock this item by beating Boss Rush with Eden.
Type: Active
Recharge Time: 6 rooms
Item Pool: Item Room
Unicorn Stump
ItemID: 298
"You feel stumped"
• When used, turns Isaac invincible and gains +0.28 speed for a 5 seconds.
• You cannot fire tears while the stump is active.
• Very similar to the My Little Unicorn item but does not deal contact damage.
• When used with Mom's Knife, you can still deal contact damage but will be unable to change the way the knife faces while the effect is active.
Type: Active
Recharge Time: 1 room
Item Pool: Item Room
Virgo
ItemID: 303
"You feel refreshed and protected"
• A random chance when you take damage to get an invincibility shield for a few seconds (Similar to the Celtic Cross effect but more likely).
• The chance to get an invincibility shield is affected by your luck stat and at +10 Luck it will activate every time you get hit.
• Converts all stat down pills into stat up pills. 'Bad Trip' turns into 'Balls of Steel' and 'Amnesia' turns into 'I can see forever'.
• One of the twelve zodiac items available in the game.
Type: Passive
Item Pool: Item Room
The Virus
ItemID: 13
"Poison touch"
• Deals poison damage on contact with enemies (Damage over time 4 or 6 per tick).
• -0.1 Speed Down. (Cached: Only applied after the speed stat is next updated)
• Has a chance to drop from the Lust miniboss fight.
In Afterbirth this item can cause enemies to drop black hearts if it was poisoned.
Type: Passive
Item Pool: Item Room, Demon Beggar, Lust Miniboss
The Wafer
ItemID: 108
"Damage resistance"
• All damage taken is reduced to half a heart.
• Damaged reduction is reduced from every source in the game except Devil Deals and health down pills.
• Does not prevent death (i.e. Suicide King or using The Bible on Isaac, ??? or Satan).
• The Wafer becomes most effective in the Womb and beyond where enemies all deal a whole heart of damage.
• The Wafer causes the Sharp Plug item to only cost 1/2 a heart per use.
Type: Passive
Item Pool: Item Room, Angel Room
We Need To Go Deeper
ItemID: 84
"Reusable level skip"
• Spawns a trapdoor at Isaac's feet which allows him to travel to the next floor.
• The trapdoor has a 10% chance to become a Black Market.
• Has no effect in Sheol, Cathedral, Chest and Dark Room.
• Cannot spawn a trapdoor directly infront of a secret room entrance.
• Can destroy rocks if used when Isaac is flying over a rock.
Type: Active
Recharge Time: 6 rooms
Item Pool: Secret Room, Devil Room
White Pony
ItemID: 181
"Flight + holy death"
• Allows Isaac to fly while the White Pony is held.
• While held, sets your speed stat to 1.5 if it isn't already that high. If your speed stat is already higher then that value is still used.
• Upon use, Isaac charges in the direction the pony is facing, becoming invulnerable during the charge and damaging enemies while also casting the effect of Crack The Sky.
• The charge of the spacebar attack deals 40 damage on contact with enemies and the beams deal 20 damage.
• Drops from the Conquest boss fight.
Type: Active
Recharge Time: 6 rooms
Item Pool: None (Conquest boss only)
Whore of Babylon
ItemID: 122
"Curse up"
• When you only have half a heart remaining or less, you enter a curse state which adds +1.5 damage and +0.3 speed.
• When playing as Eve, this item activates with one FULL heart remaining or less AND also removes her 0.75 damage multiplier, raising it up to 1.0.
• The effect is permanently active for characters with no red hearts (e.g. Blue Baby, The Lost).
• One of Eve's starting items.
Type: Passive
Item Pool: Devil Room
Wire Coat Hanger
ItemID: 32
"Tears up"
• +0.7 Tears Up.
UNLOCK: Unlock this item by beating Mom's Heart 4 times.
Type: Passive
Item Pool: Boss Room
Wooden Spoon
ItemID: 27
"Speed up"
• +0.3 Speed Up.
Type: Passive
Item Pool: Boss Room
X-Ray Vision
ItemID: 76
"I've seen everything"
• Reveals the entrance to secret rooms and automatically opens the hole, removing the need for bombs to enter.
Type: Passive
Item Pool: Item Room
Yum Heart
ItemID: 45
"Reusable regeneration"
• Heals Isaac for one whole red heart.
• Maggy starts with this item.
• Has a chance to drop from the Super Lust miniboss fight.
Type: Active
Recharge Time: 4 rooms
Item Pool: Item Room, Super Lust Miniboss
Afterbirth Items
Diplopia
ItemID: 347
"Double item vision"
• A one-time use item which when used, will duplicate any pedestal items or consumables in the current room.
• If used in a shop, the duplicated items can be taken for free.
• If used on a trinket, another random trinket will spawn instead of a duplicate.
• If used in the Boss Rush, all the duplicates can be taken for free as well as one of the original items.
Type: Active
Recharge Time: Instant (One time use)
Item Pool: Shop
Placebo
ItemID: 348
"Pill mimic"
• When used, copies the effect of the pill you are currently holding without consuming it.
• Does not copy effects of Cards or Runes.
• Can be used to generate infinite batteries with the 48 hour energy pill.
Type: Active
Recharge Time: 4 rooms
Wooden Nickel
ItemID: 349
"Flip a coin"
• When used, has a 50% chance to drop one random type of coin (penny, nickel or dime)
UNLOCK: Unlock this item by donating 33 coins to the Greed Donation Machine.
UNLOCK: Keeper starts with this item after beating Isaac with Keeper.
Type: Active
Recharge Time: 1 room
Item Pool:
Toxic Shock
ItemID: 350
"Mass poison"
• With this item, at the start of every room you will deal double your tear damage to the entire room in a poison effect.
• Enemies killed now also leave a pool of creep on the ground where they died.
• High tear damage will cause this item to become very powerful for rooms with a lot of enemies, since they can die instantly and render the room harmless.
• Enemies which spawn after the first few seconds of each room are not affected by this item, e.g. Flies spawned from a Mulligan dying.
Type: Passive
Item Pool: Item Room
Mega Bean
ItemID: 351
"Giga fart!"
• When used, the Mega Bean will freeze all enemies in the current room for a couple of seconds, deal 5 damage and poison any enemies in close proximity and send a wave of spikes across the room in the direction you are facing.
• The enemies in close range will take 5 damage then have a poison over time effect which deals your tear damage 4 or 6 times.
• The spike wave will deal 10 damage to any enemies in contact with it.
• Can be used to open secret rooms.
Type: Active
Recharge Time: 3 rooms
Item Pool: Item Room, Greed Mode Item Room
Glass Cannon
ItemID: 352
"Be gentle..."
• When used, reduces your health to half a heart and fires one large piercing spectral tear that does a lot of damage.
• This will affect all hearts including red, soul and black, reducing all of them down to half of one heart.
• The damage done by Glass Cannon scales with your damage (at base damage it does 45 damage).
Type: Active
Recharge Time: 5 seconds
Item Pool: Item Room, Greed Mode Item Room
Bomber Boy
ItemID: 353
"Explosive blast!"
• +5 bombs
• Isaac's bombs will now explode in a large cross-shaped pattern (roughly 5 bombs explosions wide).
• This also affects troll bombs.
Type: Passive
Item Pool: Item Room, Greed Mode Item Room
Crack Jacks
ItemID: 354
"Don't swallow the prize!"
• +1 Health Up
• Spawns a random trinket on the floor.
Type: Passive
Item Pool: Boss Room
Mom's Pearls
ItemID: 355
"Range + luck up"
• +1.25 Range Up.
• +0.5 Tear Height.
• +1 Luck Up.
Type: Passive
Item Pool: Boss Room
Car Battery
ItemID: 356
"Double charge!"
• The Car Battery causes your spacebar item to activate twice on each use.
• For example, with Yum Heart you would heal 2 full red hearts instead of 1.
Type: Passive
Item Pool: Shop, Greed Mode Shop
Box of Friends
ItemID: 357
"Double your friends"
• Upon use, gives you a duplicate of each familiar you have for the current room.
• It will not 'double' your familiars in the sense that if you have 2 of one kind, it will only give you an extra one.
• If the familiar only appears when taking damage (i.e. Dead Bird) then Box of Friends will cause it to spawn but won't create duplicates.
• This can be used multiple times in the same room to generate more familiars, meaning you can get a level 4 meatboy or bandage girl by using this item 3 times in the same room.
• If used when you have no familiars, it will give you a Demon Baby temporarily.
• Lilith starts with this item.
UNLOCK: Unlock this item by beating Greed Mode with Lilith.
Type: Active
Recharge Time: 4 rooms
Item Pool: Shop, Greed Mode Item Room
The Wiz
ItemID: 358
"Double wiz shot!"
• Isaac wears a dunce hat and fires 2 tears at once diagonally, similar to the R U A WIZARD pill tear pattern.
• Gives Isaac spectral tears which allows them to travel through objects in the environment (i.e. rocks).
Type: Passive
Item Pool: Item Room, Greed Mode Item Room
8 Inch Nails
ItemID: 359
"Stick it to 'em!"
• +1.5 Damage Up.
• Replaces Isaac's tears with nails, which have increased knockback.
• The increased knockback will also affect Brimstone, which usually has no knockback at all.
Type: Passive, Tear Modifier
Item Pool: Item Room, Greed Mode Item Room
Incubus
ItemID: 360
"Dark friend"
• Gives you a familiar demon incubus that follows you and shoots tears exactly the same as Isaac's in terms of damage, stats and also effects.
• It will mimic any tear effects you currently have and also copy your current stats, meaning it will fire with the same damage, fire rate and range.
• Incubus' tear damage will scale with any future damage ups and stat upgrades you take.
• Lilith starts with this item.
UNLOCK: Unlock this item by beating Blue Womb (Hush) with Lilith.
Type: Passive, Familiar
Item Pool: Devil Room, Greed Mode Devil Room
Fate's Reward
ItemID: 361
"Your fate beside you"
• A familiar blue head that will follow Isaac and fire tears copying his tear damage.
• This familiar is very similar to Incubus, however it only copies damage and is not affected by tears or range upgrades.
UNLOCK: Unlock this item by beating Blue Womb (Hush) with ??? (Blue baby).
Type: Passive, Familiar
Item Pool: Item Room, Gold Chest
Lil Chest
ItemID: 362
"What's in the box?"
• A familiar chest that follows Isaac and will drop a random pickup every few rooms.
UNLOCK: Unlock this item by beating Greed Mode with Isaac.
Type: Passive, Familiar
Item Pool: Item Room, Greed Mode Item Room, Beggar
Sworn Protector
ItemID: 363
"Protective friend"
• An orbital angel which does 7 contact damage per tick and blocks shots.
• The angel will attract bullets towards it and block them.
• After blocking a tear, this orbital has a chance to drop an eternal heart.
• Visually this is almost identical to the Guardian Angel item, but without a face.
UNLOCK: Unlock this item by beating Blue Womb (Hush) with The Lost.
Type: Passive, Familiar
Item Pool: Angel Room, Greed Mode Angel Room
Friend Zone
ItemID: 364
"Friendly fly"
• A white orbiting fly which deals 3 contact damage per tick to enemies.
• This familiar orbits Isaac at a middle length distance somewhere between Distant Admiration and Forever Alone
Type: Passive, Familiar
Item Pool: Item Room, Greed Mode Item Room, Key Beggar
Lost Fly
ItemID: 365
"Lost protector"
• A familiar fly that moves in a straight line and attaches itself to the first obstacle or wall it comes into contact with in each room.
• If any enemies walk into its path, it will deal 7 contact damage per tick.
• If the obstacle it is attached to is destroyed then it will continue rolling in the direction it was previously travelling until it meets another wall or obstacle.
Type: Passive, Familiar
Item Pool: Item Room, Greed Mode Item Room, Key Beggar
Scatter Bombs
ItemID: 366
"We put bombs in your bombs!"
• +5 bombs
• Causes your bombs to explode into 4 tiny bombs
Type: Passive
Item Pool: Item Room, Greed Mode Item Room
Sticky Bombs
ItemID: 367
"Egg sack bombs!"
• When one of your bombs kills an enemy, a bunch of blue spiders are spawned to fight by your side.
• This item also causes your bombs to stick to enemies.
Type: Passive, Bomb Modifier
Item Pool: Item Room, Greed Mode Item Room, Bomb Beggar
Epiphora
ItemID: 368
"Intensifying tears"
• Shooting in one direction increases your fire rate until a cap is reached.
• The maximum effect is to halve your delay, which takes roughly 10 seconds to achieve.
• The accuracy of your tears is also reduced as your fire rate increases.
• As soon as you change direction or interupt shooting, your fire rate is reset to its normal amount.
Type: Passive
Item Pool: Item Room, Greed Mode Item Room
Continuum
ItemID: 369
"Transcendent tears"
• +2.25 Range Up.
• +1.5 Tear Height.
• Tears will now travel through walls and appear out of the opposite wall, similar to a portal-type mechanic.
• Your tears can now also travel over rocks and objects in the environment.
Type: Passive
Item Pool: Item Room, Greed Mode Item Room
Mr. Dolly
ItemID: 370
"Range + tears up"
• +0.7 Tears Up.
• +5.25 Range Up.
• +0.5 Tear Height.
• Spawns 3 random types of hearts on the floor when picked up
Type: Passive
Item Pool: Boss Room
Curse of The Tower
ItemID: 371
"You feel cursed..."
• Causes Isaac to spawn 6 troll bombs on the floor every time he gets hit, similar to the Anarchist Cookbook mechanic.
Type: Passive
Item Pool: Item Room, Red Chest, Curse Room, Greed Mode Item Room
Charged Baby
ItemID: 372
"Bbbzzzzzt!"
• A familiar baby that has a random chance to drop a battery pickup or freeze all enemies in the room for a short while.
• Charged Baby also has a chance to add one charge to your spacebar item.
• These effects can only occur while in a hostile room with enemies.
Type: Passive, Familiar
Item Pool: Shop, Greed Mode Shop
Dead Eye
ItemID: 373
"Accuracy brings power!"
• Gives Isaac a +25% damage up for every tear that successfully hits an enemy.
• After 5 damage increases, the bonus from Dead Eye maxes out at double your damage.
• After missing 3 consecutive shots, you lose your damage bonus.
• Piercing shots work with this item and multiple hits with a single tear will each give a damage bonus.
Type: Passive
Item Pool: Item Room, Greed Mode Item Room
Holy Light!
ItemID: 374
"Holy shot!"
• Isaac has a random chance to fire a Holy tear, which when it hits an enemy, will spawn a Crack the Sky style light beam on the same enemy, dealing damage.
• The beams from this item deal damage equal to 300% of your tear damage (3x damage multiplier for the beams only).
Type: Passive
Item Pool: Item Room, Greed Mode Item Room, Angel Room
Host Hat
ItemID: 375
"Nice hat!"
• A familiar host that sits on Isaac's head and has a random chance to deflect some tears so that they don't hit you.
• Causes you to become immune to explosions. Stomp damage (i.e. Mom's Foot boss) counts as an explosion and is therefore prevented by Host Hat.
Type: Passive
Item Pool: Item Room, Greed Mode Item Room
Restock
ItemID: 376
"Never ending stores!"
• Causes your shops to instantly restock their items when you buy them.
Type: Passive
Item Pool: Shop, Beggar
Bursting Sack
ItemID: 377
"Spider love"
• Spider enemies no longer target or deal contact damage to Isaac.
• This is very similar to a Skatole for spiders instead of flies.
Type: Passive
Item Pool: Item Room, Greed Mode Item Room
No. 2
ItemID: 378
"Uh oh..."
• Continuously firing or charging tears for 3 seconds causes Isaac to drop a Butt Bomb
• Only 1 Butt Bomb can be dropped per charge, so you'll need to stop firing then start again to drop another one.
• Butt Bombs explode for 50 damage like normal bombs, but also deal 10 damage to all enemies in the room and daze them for a short period of time.
Type: Passive
Item Pool: Item Room, Greed Mode Item Room
Pupula Duplex
ItemID: 379
"Wide shot"
• Transforms Isaac's tears into a wide arc shape which gives them a much larger hitbox.
• Gives Isaac spectral tears which allows them to travel through objects in the environment (i.e. rocks).
Type: Passive
Item Pool: Item Room, Greed Mode Item Room
Pay To Play
ItemID: 380
"Money talks"
• +5 coins.
• This item turns all doors that require a key into doors which need a coin to enter instead.
• This affects shops, item rooms, libraries and other key doors.
Type: Passive
Item Pool: Shop, Greed Mode Item Room, Greed Mode Shop
Eden's Blessing
ItemID: 381
"Your future shines brighter"
• +0.7 Tears Up.
• Gives you a random item at the start of your next run (You need to start a fresh run to receive the item)
UNLOCK: Unlock this item by beating Blue Womb (Hush) with Eden.
Type: Passive
Item Pool: Item Room
Friendly Ball
ItemID: 382
"Gotta fetch 'em all!"
• When used, can be thrown at enemies to capture them (similar to a Poké Ball).
• After capturing an enemy, the next use of the Friendly Ball will re-spawn the same enemy as a friendly companion which will attack other enemies.
• The companion will persist between rooms and floors until it dies by taking enough damage.
Type: Active
Recharge Time: 3 rooms.
Item Pool: Item Room, Greed Mode Item Room
Tear Detonator
ItemID: 383
"Remote tear detonation"
• When used, will detonate any tears currently on the screen and cause each one to split into 6 more tears which will fire in a circle, similar to Tammy's Head.
Type: Active
Recharge Time: 1 room.
Item Pool: Shop, Greed Mode Item Room
Lil Gurdy
ItemID: 384
"A gurd of your own!"
• Gives Isaac a familiar Gurdy that will charge around the room dealing contact damage to enemies.
• The Gurdy is charged by holding down the fire button and letting go. The longer the button is held the faster Gurdy will fling itself across the screen.
• Lil Gurdy can glide over the top of objects and obstacles in the room.
Type: Passive, Familiar
Item Pool: Item Room, Greed Mode Item Room
Bumbo
ItemID: 385
"Bumbo want coin!"
• A beggar head which floats around the room and picks up any near-by coins. Every 6 coins Bumbo will evolve to a new form except for level 4 which takes 12 coins.
• Level 2: Bumbo gains a body and crawls around the room.
• Level 3: It now fires tears in the same direction Isaac does.
• Level 4: Bumbo no longer fires tears but instead will chase enemies slowly and deal contact damage. It will also sometimes randomly drop bombs.
• After reaching level 4, Bumbo will also continue to collect coins and drop random pickups, similar to the Bum Friend item.
Type: Passive, Familiar
Item Pool: Item Room, Beggar
D12
ItemID: 386
"Rerolls rocks"
• When used, the D12 re-rolls any rocks into another random type of object (e.g. poop, pots, TNT, red poop, stone blocks etc.)
UNLOCK: Unlock this item by beating Blue Womb (Hush) with Cain.
Type: Active
Recharge Time: 3 rooms
Item Pool: Item Room, Greed Mode Shop
Censer
ItemID: 387
"Peace be with you"
• Gives Isaac a familiar golden Censer which creates a huge aura of light that slows down any enemies inside it.
UNLOCK: Unlock this item by beating Greed Mode with Maggy.
Type: Passive, Familiar
Item Pool: Angel Room, Greed Mode Angel Room
Key Bum
ItemID: 388
"He wants your keys!"
• A familiar beggar similar to Bum Friend that follows Isaac and collects keys, giving random chests in return.
• One of the 3 items required to create the Super Bum familiar transformation.
UNLOCK: Unlock this item by beating Greed Mode with Lazarus.
Type: Passive, Familiar
Item Pool: Item Room, Secret Room, Key Beggar
Rune Bag
ItemID: 389
"Rune generator"
• A bag that follows Isaac and drops a random mystic rune every 3 rooms.
UNLOCK: Unlock this item by beating the Isaac boss with Lilith.
Type: Passive, Familiar
Item Pool: Item Room, Secret Room, Greed Mode Item Room
Seraphim
ItemID: 390
"Sworn friend"
• A familiar angel which follows Isaac and fires Sacred Heart tears which deal 10 damage at -25% shot speed and a reduced fire rate.
Type: Passive, Familiar
Item Pool: Item Room, Angel Room, Greed Mode Angel Room
Betrayal
ItemID: 391
"Turn your enemy"
• Every time Isaac takes damage, a charm effect is applied to every enemy in the room, causing them to attack each other rather than Isaac.
UNLOCK: Unlock this item by beating Blue Womb (Hush) with Judas.
Type: Passive
Item Pool: Item Room, Greed Mode Item Room, Devil Room, Greed Mode Devil Room
Zodiac
ItemID: 392
"The heavens will change you"
• Zodiac will give you a random zodiac item effect that changes after every floor.
• Possible item effects include: Taurus, Aries, Cancer, Leo, Virgo, Libra, Scorpio, Sagittarius, Capricorn, Aquarius, Gemini or Pisces.
UNLOCK: Unlock this item by beating Greed Mode with The Lost.
Type: Passive
Item Pool: Item Room, Greed Mode Item Room
Serpent's Kiss
ItemID: 393
"The kiss of death"
• Tears now have a random chance to apply a poison effect, causing 4 or 6 damage per tick to enemies (Similar to The Common Cold item).
• Isaac now deals poison damage on contact with enemies similar to The Virus item (Damage over time 4 or 6 per tick).
• Enemies that were poisoned have a chance to drop a black sin heart when killed.
UNLOCK: Unlock this item by beating Satan with Lilith.
Type: Passive
Item Pool: Item Room, Greed Mode Item Room
Marked
ItemID: 394
"Directed tears"
• Isaac will now fire tears automatically directed at a red target on the ground which is controlled by the player.
• This allows for a full 360 degree tear firing radius.
• Can be overridden by other tear modifiers such as Mom's Knife or Brimstone.
• +0.7 Tears Up.
• +0.3 Tear Height.
• +3.15 Range Up.
Type: Passive
Item Pool: Item Room, Greed Mode Item Room
Tech X
ItemID: 395
"Laser ring tears"
• Tears are replaced with the ability to charge and fire a laser ring that travels across the room.
• The size of the ring will depend on how long you charge it.
• The laser ring does damage equal to your normal tears rapidly to any enemies inside the ring.
Type: Passive, Tear modifier
Item Pool: Item Room, Greed Mode Item Room
Ventricle Razor
ItemID: 396
"Short cutter"
• Allows you to create one brown tunnel and one blue tunnel in the floor, that can be used to teleport between wherever you placed each one.
• This item will let you port out of the devil room but not back into it.
• Very useful in the boss rush and challenge rooms.
Type: Active
Recharge Time: Instant
Item Pool: Shop
Tractor Beam
ItemID: 397
"Controlled tears"
• Isaac's tears now travel directly forwards following a beam of light, but will also move sideways based on your player movement.
• +0.5 Tears Up.
• +5.25 Range Up.
• +0.16 Shot Speed Up.
• +0.5 Tear Height.
• Allows for more accurate correction when firing tears, as their direction can be controlled even after they have been fired.
• If you switch the direction in which you are firing tears, the beam of light and all your tears will also be transported to the new direction
Type: Passive, Tear Modifier
Item Pool: Item Room, Greed Mode Item Room
God's Flesh
ItemID: 398
"Shrink shot!"
• Tears now have a random chance to apply a shrinking effect, causing enemies to shrink in size and also run away from Isaac.
• Shrunk enemies can be crushed and killed by walking over them.
Type: Passive
Item Pool: Item Room, Greed Mode Item Room
Maw of The Void
ItemID: 399
"Consume thy enemy!"
• +1.0 Damage Up.
• +0.5 Tear Height.
• After firing tears for 3 seconds, a red cross appears on Isaac's head that, upon releasing the fire button, creates a black ring which deals a lot of damage to any enemies inside it.
• The ring deals damage equal to your tear damage rapidly to any enemies in contact with it.
• Enemies killed with the black ring have a chance to drop Black hearts.
• You have to keep the fire button held down for the full 3 seconds to cause this effect.
UNLOCK: Unlock this item by beating Blue Womb (Hush) with Azazel.
Type: Passive
Item Pool: Devil Room, Greed Mode Devil Room
Spear of Destiny
ItemID: 400
"Your destiny"
• In addition to tears, Isaac now holds a spear infront of him which deals damage equal to 2 times your tear damage.
• The spear cannot be thrown like Mom's Knife but deals damage while it is in contact with an enemy.
Type: Passive
Item Pool: Angel Room, Greed Mode Angel Room
Explosivo
ItemID: 401
"Sticky bomb shot!"
• Tears now have a random chance to become sticky bombs, which will attach to enemies and explode after a few seconds.
• The bomb explosion deals your tear damage + 60.
Type: Passive
Item Pool: Item Room, Greed Mode Item Room
Chaos
ItemID: 402
"!!!"
• Chaos causes all item pedestals to now be choose from a random item pool instead of the pre-defined ones which normally exist.
• If an item is chosen from an exhausted pool, it will spawn a Breakfast item instead.
• When picked up also drops between 1-6 random pickups on the floor.
Type: Passive
Item Pool: Shop, Greed Mode Shop
Spider Mod
ItemID: 403
"Mod buddy!"
• A familiar grey spider that wanders around and allows you to see your tear damage and the health bars of all enemies.
• The spider will inflict a random status effect on any enemies it comes into contact with (e.g. slow, shrink, fear).
• Spider Mod will also randomly drop battery consumables.
• For the sake of simplicity for players, all damage values displayed are multiplied by 10 and rounded to the nearest number. The actual damage values are in reality about 1/10.
• This item is a reference to Spider853, creator of Spidermod for the original game and one of the lead developers that worked on Rebirth and Afterbirth.
Type: Passive
Item Pool: Shop, Greed Mode Shop
Farting Baby
ItemID: 404
"He farts!"
• A familiar that follows Isaac and blocks tears.
• If a tear hits Farting Baby, there is a high chance for it to fart, which deals damage to nearby enemies and charms them.
UNLOCK: Unlock this item by beating Blue Womb (Hush) with Isaac.
Type: Passive, Familiar
Item Pool: Item Room
GB Bug
ItemID: 405
"Game breaking bug, right away!"
• A glitch familiar that bounces around the room and applies a random status effect to any enemies it comes into contact with (e.g. slow, burning)
• If the GB Bug passes over a consumable, it has a chance to reroll it into another random consumable.
UNLOCK: Unlock this item by beating Greed Mode with Eden.
Type: Passive
Item Pool: Item Room, Secret Room, Greed Mode Shop
D8
ItemID: 406
"Reroll stats"
• When used, the D8 rerolls all of your stats!
• Will only effect your damage, tears, range and speed stats.
UNLOCK: Unlock this item by beating Challenge #28 (Pride Day).
Type: Active
Recharge Time: 4 Rooms
Item Pool: Item Room, Greed Mode Shop
Purity
ItemID: 407
"Aura stat boost"
• Purity will boost one of Isaac's stats depending on the colour of the aura around him.
• When you take damage, the aura will be removed and replaced with another random one when you enter the next room.
• Colour code is as follows:
• Red = +4.0 Damage
• Blue = -4 Tear Delay
• Yellow = +0.5 Speed Up
• Orange = +7.5 Range Up
UNLOCK: Unlock this item by beating Blue Womb (Hush) with Maggy.
Type: Passive
Item Pool: Item Room, Greed Mode Item Room, Greed Mode Angel Room
Athame
ItemID: 408
"Call to the void"
• Now when you take damage, a black ring will appear around Isaac that damages any enemies in contact with it.
• Enemies killed with the black ring have a chance to drop black hearts.
UNLOCK: Unlock this item by beating Blue Womb (Hush) with Eve.
Type: Passive
Item Pool: Devil Room, Curse Room, Greed Mode Devil Room
Empty Vessel
ItemID: 409
"I reward an empty vessel"
• +2 Black Hearts
• When Isaac has no red hearts, this item gives Isaac the ability to fly and chance to trigger a shield that nullifies all types of damage for 10 seconds.
• As soon as Isaac has half a red heart or more, this item deactivates.
UNLOCK: Unlock this item by beating Blue Womb (Hush) with Lazarus.
Type: Passive
Item Pool: Devil Room, Greed Mode Devil Room
Evil Eye
ItemID: 410
"Eye shot!"
• While firing tears this item gives you a chance to fire an eye across the screen with a very slow shot speed, which will fire tears of its own in the same direction as Isaac.
• The evil eye shots will be destroyed if they come into contact with enemies or obstacles.
UNLOCK: Unlock this item by beating Greed Mode with Cain.
Type: Passive
Item Pool: Item Room, Greed Mode Item Room
Lusty Blood
ItemID: 411
"Their blood brings rage!"
• Each time Isaac kills an enemy, you get a temporary damage up which lasts for the current room.
• Each subsequent kill will stack further damage up to a maximum of +5 Damage Up after 9 kills.
• This item is the same principle as the Bloody Lust item from the original flash game.
UNLOCK: Unlock this item by beating Greed Mode with Samson.
Type: Passive
Item Pool: Item Room, Greed Mode Item Room
Cambion Conception
ItemID: 412
"Feed them hate"
• After taking enough damage you will gain a permanent demon familiar.
• Possible familiars include: Dark Bum, Demon Baby, Leech, Lil' Brimstone, Succubus.
• The effect is shown visually in 3 stages with the character's belly getting larger each time until it finally gives birth to a familiar.
• This item is the demonic counterpart to Immaculate Conception.
• Lilith starts with this item.
UNLOCK: Unlock this item by beating ??? with Lilith.
Type: Passive
Item Pool: Devil Room, Greed Mode Devil Room
Immaculate Conception
ItemID: 413
"Feed them love"
• After picking up enough hearts, Isaac gains a permanent angelic familiar.
• Possible familiars include: Holy Water, Guardian Angel, Sworn Protector, The Relic and Seraphim
• It is possible to get multiple followers by continuing to pick up hearts.
• This item is the angelic counterpart to Cambion Conception.
UNLOCK: Unlock this item by beating Boss Rush with Lilith.
Type: Passive
Item Pool: Angel Room, Greed Mode Angel Room
More Options
ItemID: 414
"There are even more options!"
• Two items now spawn in each of your item rooms, however only one can be taken and the other will disappear
Type: Passive
Item Pool: Shop
Crown of Light
ItemID: 415
"The untainted gain power"
• +2 Soul Hearts.
• A crown that replaces normal tears with blue diamond tears while you don't have any empty red heart containers.
• While the effect is active, tears do double damage.
• The crown will glow blue while active, if inactive it will appear grey.
• The effect will also deactivate for the rest of the current room when you take damage, regardless of your health.
Type: Passive
Item Pool: Angel Room, Greed Mode Angel Room
Deep Pockets
ItemID: 416
"More stuff to carry!"
• Allows you to carry two cards/pills/runes at the same time.
UNLOCK: Unlock this item by beating The Chest floor with Keeper.
Type: Passive
Item Pool: Shop, Greed Mode Item Room, Greed Mode Shop
Succubus
ItemID: 417
"Damage booster"
• A flying familiar that bounces around the room with a damaging aura, dealing rapid damage to any enemies inside it and boosting Isaac's tear damage.
• While standing in the black aura, Isaac has a temporary 1.5x damage multiplier (this will stack if you have more than one Succubus')
UNLOCK: Unlock this item by beating The Lamb with Lilith.
Type: Passive, Familiar
Item Pool: Devil Room, Demon Beggar
Fruit Cake
ItemID: 418
"Rainbow effects!"
• Gives you a different tear effect with every tear that you fire.
• Tear effects include: Anti-Gravity, GodHead, Proptosis, Tiny Planet, Holy Light, Soy Milk, Cricket's Body, Explosivo, Continuum, My Reflection, Ring Worm, Hook Worm, Wiggle Worm, Flat Worm.
• With Dr. Fetus, this item will also cycle through random Bomb Modifiers (e.g. Butt Bombs, Hot Bombs).
Type: Passive, Tear Modifier
Item Pool: Item Room
Teleport 2.0
ItemID: 419
"I-teleport!"
• When used will teleport you to another random room that has not been explored yet.
• After all the normal rooms have been explored, the hierarchy of rooms chosen is: Super Secret Room, Shop, Item Room, Secret Room, Curse Room, Sacrafice Room, Devil/Angel Room, I Am Error.
• This ordering means a Devil and I Am Error room can both be forced if all others have been visited.
• If used in a normal room with enemies it will teleport you out and back into the exact same room.
Type: Active
Recharge Time: 4 rooms
Item Pool: Item Room
Black Powder
ItemID: 420
"Spin the black circle!"
• Walking in a circle will spawn a pentagram symbol on the floor, which deals 10 damage per tick to any enemies inside it.
• The trail of black powder left on the floor will quickly disappear, meaning you are limited on the size of the pentagram symbol you can create.
Type: Passive
Item Pool: Devil Room, Greed Mode Devil Room
Kidney Bean
ItemID: 421
"Love toots!"
• When used, applies the charm effect to any enemies in close range.
• Charmed enemies will prioritize attacking other enemies in the room, otherwise they will still attack Isaac.
Type: Active
Recharge time: 2 Rooms
Item Pool: Item Room, Greed Mode Item Room
Glowing Hour Glass
ItemID: 422
"Turn back time"
• When used, this item will rewind time and put you back in the previous room, in the same state you were in at that moment.
• This means any damage taken or consumables used in the current room will be reset back to the previous state.
Type: Active
Recharge time: 2 rooms
Item Pool: Item Room, Shop
Circle of Protection
ItemID: 423
"Protect me from myself"
• Gives Isaac a large white halo around him, that deals a bit of damage to any enemies in contact with the ring.
• Every time an enemy bullet enters the ring, there is a chance it will reflect a homing tear back at the enemy.
Type: Passive
Item Pool: Angel Room, Greed Mode Angel Room
Sack Head
ItemID: 424
"More sacks!"
• All bomb, coin, key, and battery pickups pickups now have a chance to be replaced with a sack that contains multiple pickups.
• Can lead to game-breaking combinations with the D20 due to the amount of consumables and batteries spawned by the item sacks.
Type: Passive
Item Pool: Shop
Night Light
ItemID: 425
"Scared of the dark?"
• Gives Isaac a cone of light infront of him that slows any enemies inside it and their tears.
• The light faces the direction that you are facing, not the direction you are firing.
• Removes Curse of Darkness for the current floor, if picked up on a floor where the curse is active.
Type: Passive
Item Pool:
Obsessed Fan
ItemID: 426
"Follows my every move...""
• A purple familiar fly that follows your exact movement on a 3 second delay and deals contact damage to enemies.
Type: Passive, Familiar
Item Pool: Item Room, Greed Mode Item Room
Mine Crafter
ItemID: 427
"Booom!"
• When used, places an explosive TNT barrel next to you.
• The TNT barrel can be pushed and used to explode rocks or damage enemies.
• If used a second time in the same room while the last TNT barrel is still there, it will remotely explode the first TNT and not spawn another.
Type: Active
Recharge time: 1 room
Item Pool: Item Room
PJs
ItemID: 428
"You feel cozy"
• +4 Soul Hearts
• Fully restores your red health.
Type: Passive
Item Pool: Boss Room
Head of the Keeper
ItemID: 429
"Penny tears!"
• Isaac's tears become coins and now have a chance to drop pennies on the floor upon successfully hitting an enemy.
• Has a chance to drop when exploding a dead shopkeeper and also appear in the Gold Chest pool.
Type: Passive
Item Pool: Gold Chest, Greed Mode Gold Chest, Dead shopkeeper
Papa Fly
ItemID: 430
"Turret follower"
• A familiar blue fly that will follow Isaac's movement pattern but delayed by 3 seconds.
• Papa Fly will fire tears at nearby enemies that deal damage equal to Isaac's tear damage.
Type: Passive, Familiar
Item Pool: Item Room, Greed Mode Item Room
Multidimensional Baby
ItemID: 431
"ydduB Buddy"
• A familiar baby that will follow your movement pattern on a 3 second delay. Tears that pass through the baby will double up and increase in damage while flashing black & white.
Type: Passive, Familiar
Item Pool: Item Room, Greed Mode Item Room, Devil Room, Greed Mode Devil Room
Glitter Bombs
ItemID: 432
"Prize bombs!"
• Isaac's normal bombs become pink and causes them to drop random pickups when they explode (e.g. keys, coins, bombs).
Type: Passive, Bomb Modifier
Item Pool: Item Room, Greed Mode Item Room
My Shadow
ItemID: 433
"Me! And my shaaaadow!"
• Each time you take damage, My Shadow will apply a fear effect to all enemies in the room and spawn a familiar black charger that will attack for you.
• The charger will be killed if it is damaged too much.
UNLOCK: Unlock this item by beating Greed Mode with Judas.
Type: Passive
Item Pool: Devil Room, Greed Mode Devil Room
Jar of Flies
ItemID: 434
"Gotta catch 'em all?"
• Every time you kill an enemy a fly will be added to the Jar, allowing you to stack up to 20.
• Using the Jar of Flies will release all the flies that are currently in the jar as friendly flies that will damage enemies.
Type: Active
Recharge time: Instant
Item Pool: Shop, Greed Mode Item Room, Greed Mode Shop
Lil Loki
ItemID: 435
"4-way buddy!"
• A Loki familiar that follows Isaac and shoots tears 4 tears in a cross pattern.
Type: Passive
Item Pool: Item Room
Milk!
ItemID: 436
"Dont cry over it..."
• Gives Isaac a familiar glass of milk that follows him and spills on the floor upon taking damage.
• After being spilt, the milk gives you a Tears Up for the rest of the room.
Type: Passive, Familiar
Item Pool: Item Room, Greed Mode Item Room
D7
ItemID: 437
"Reroll rewards!"
• When used, the D7 will restart the current room and bring back all enemies once again, enabling you to farm rewards that spawn at the end after beating the room.
• Can be used to generate infinite consumable combinations, gaining as many coins/keys/bombs as you need.
• Will teleport you to out of the room if used in a Boss Room or Devil Room.
• If used in a greed fight it can be used to reroll the room into a Shop.
Type: Active
Recharge time: 3 rooms
Item Pool: Item Room
Binky
ItemID: 438
"Memories..."
• +1 Soul heart
• +0.7 Tears Up.
• Makes Isaac very small like a baby, reducing his hitbox size.
Type: Passive
Item Pool: Boss Room
Mom's Box
ItemID: 439
"What's inside?"
• When used, Mom's Box will drop a random trinket on the ground.
• +1 Luck while held.
• While held, doubles the effect of trinkets which make sense to be doubled (e.g. +4 damage from Curved Horn instead of 2, -4 Tear Delay from Cancer instead of 2)
Type: Active
Recharge time: 4 rooms
Item Pool: Shop, Greed Mode Shop
Kidney Stone
ItemID: 440
"Matt's kidney stone"
• Randomly while firing tears, Isaac will stop firing and turn red, where he will charge and release a lot of 'tears' in one go. In the burst of tears is a kidney stone which deals a lot of damage.
• -0.2 Speed Down.
• -15 Range Down.
• +2.0 Tear height
• The large decrease in range and tear height increase cause this item to overall be a slight range down.
UNLOCK: Unlock this item by beating Challenge #29 (Onan's Streak).
Type: Passive
Item Pool: Item Room, Greed Mode Item Room
Mega Blast
ItemID: 441
"Laser breath"
• Upon use, fires a huge Mega Satan laser for 15 seconds, dealing massive damage to anything in its path and pushing Isaac back by the force.
• The laser persists for the entire 15 seconds even between rooms and floors.
• This item appears in the Devil Room but is weighted to be about 5 times rarer than all other devil room items.
UNLOCK: Unlock this item by beating Mega Satan with every character.
Type: Active
Recharge time: 12 rooms.
Item Pool: Devil Room, Greed Mode Devil Room
Rebirth Trinkets
???'s Soul
"Imaginary friend"
• Creates a familiar which moves around the room in a similar fashion to The Peeper, shooting tears in the same direction as Isaac.
UNLOCK: Unlock this item by beating the Dark Room with Blue Baby.
AAA Battery
"Trickle charge"
• Lowers your spacebar item charge rate by 1.
• Cannot lower the charge of your spacebar item below 1 room.
• For example, you will now be able to use a 3 room charge item after 2 rooms instead.
Ace of Spades
"Luck of the draw"
• Gives Isaac a higher chance to find Tarot cards after clearing a room or from chests.
Bible Tract
"Faith up"
• Gives you a higher chance of eternal hearts.
• Contrary to popular belief, the Bible Tract doesn't allow Angel Rooms to appear after paying for a Devil Deal.
Black Lipstick
"Evil up"
• Increases the chance for Black hearts to spawn.
UNLOCK: Unlock this item by beating the Dark Room with Eve.
Bloody Penny
"Wealth of health"
• Everytime you pick up a penny, you have a chance to spawn a red heart on the floor.
UNLOCK: Unlock this item by beating the Chest with Samson.
Broken Magnet
"It kinda works"
• Has a partial Magneto effect and will attract coins, pulling them into Isaac from a distance.
• Does not attract other pickups like the full Magneto item does.
Broken Ankh
"Eternal life?"
• Has a chance (roughly 20%) to respawn with 3 Soul hearts as Blue Baby when you die.
UNLOCK: Unlock this item by beating Satan with Lazarus.
Broken Remote
"It's broken"
• Does the teleport effect every time you use your current spacebar item.
• Can be used infinitely every room if you have Guppy's Paw and no red heart containers (Can be exploited to get to the boss room without clearing any other rooms).
Burnt Penny
"Wealth of chaos"
• Everytime you pick up a coin, you have a chance to spawn a bomb on the floor.
UNLOCK: Unlock this item by beating Challenge #13 (Beans!).
Butt Penny
"Wealth of gas"
• Everytime you pick up a coin, you fart.
Cain's Eye
"May you see your destination
• Gives a 25% chance to reveal map icons at the start of a new floor (The same effect as the Compass).
UNLOCK: Unlock this item by beating the Chest with Cain.
Callus
"Your feet feel stronger"
• Isaac no longer takes damage from walking over spikes and blood creep while this trinket is held.
Cancer
"Yay, cancer!"
• -2 Tear Delay (Tears Up).
• The fire rate increase is applied in such a way that the higher your tear stat is, the more effective Cancer is.
• Breaks the normal fire rate cap, allowing you to fire faster than the normal maximum.
Cartridge
"I remember these"
• When Isaac takes damage, there is a chance he will gain the Gamekid effect, turning him invincible and dealing contact damage to any enemies he touches.
• The chance to activate the invincibility effect is affected by your luck stat and at +38 Luck it will activate every time you get hit.
Child's Heart
"It calls out to its brothers"
• Gives Isaac a higher chance to find hearts from drops after clearing a room and from chests.
Counterfeit Penny
"Wealth of wealth"
• When picking up a coin, you have a chance to automatically gain one more coin.
UNLOCK: Unlock this item by playing the shell game in the arcade 100 times.
Cursed Skull
"Cursed?"
• When you take damage while on 1/2 a heart, you are teleported back to the previous room.
Curved Horn
"DMG up"
• +2 Damage Up
UNLOCK: Unlock this item by beating the Dark Room with Judas.
Daemon's Tail
"Evil up"
• When Daemon's Tail is held, most future Heart drop will be rerolled into something else, with a certain chance to be rerolled into a Black Heart.
• Every type of heart will be affected (except for hearts spawned in Super Secret Rooms) and causes Mitre, Bible Tract, Mom's Pearl to become useless.
• Upon entering a new room that already has hearts on the ground, they will all be converted into Black Hearts.
• Hearts that spawn after clearing a room, opening a chest or playing a slot machine/beggar will be re-rolled into another possible pickup that could appear. This essentially means you are sacrificing your heart drops for a higher chance of all other pickups
UNLOCK: Unlock this item by beating Satan with Azazel.
Eve's Bird Foot
"Revenge from beyond"
• When you kill an enemy, you have a chance to spawn a transparent Dead Bird familiar.
• The Dead Bird familiar deals 2 damage per tick to enemies while in contact with them.
UNLOCK: Unlock this item by beating the Isaac boss with Eve.
Fish Head
"It stinks"
• Everytime Isaac takes damage, one blue fly will spawn.
Flat Penny
"Wealth of answers"
• Everytime you pick up a coin, you have a chance to spawn a key.
Flat Worm
"Blub blub!"
• Tears become flat and disc shaped giving them a larger hitbox.
• Higher knockback effect with your tears.
Goat Hoof
"Speed up"
• +0.15 Speed Up.
Hook Worm
"Zip zoop!"
• Tears now move forwards at right angles, shifting left and right across the room.
• Increases your range stat by +10.0 while held but due to the fire pattern, your tears travel a similar distance to normal.
Isaac's Fork
"Consume thy enemy"
• After clearing a room, you have a chance to heal for half a red heart.
Isaac's Head
"Dead friend"
• While held, this trinket gives Isaac a familiar that shoots piercing tears that deal 3.5 damage.
UNLOCK: Unlock this item by beating the Boss Rush with Isaac.
Judas' Tongue
"Payment received"
• Items which cost 2 heart containers in a deal with the devil are reduced to only cost 1 heart.
UNLOCK: Unlock this item by beating Satan with Judas.
The Left Hand
"The left hand path reaps dark rewards"
• Replaces chest spawns with red chests.
UNLOCK: Unlock this item by beating Ultra Pride.
Liberty Cap
"Touch fuzzy, get dizzy!"
• While held, this trinket gives a random mushroom effect each room
• Possible mushrooms include: Mini Mush, Odd Mushroom (Thin), Odd Mushroom (Thick), The Compass.
Lucky Rock
"There's something inside"
• Rocks now drop money when broken.
UNLOCK: Unlock this item by destroying 100 rocks.
Lucky Toe
"Luck up!"
• +1 Luck Up while held.
UNLOCK: Unlock this item by blowing up 20 shop keepers (this includes the ones in the secret room).
Maggy's Faith
"Faith's reward"
• At the start of a new floor, you get an eternal heart.
UNLOCK: Unlock this item by beating the Dark Room with Maggy.
Match Stick
"Tastes like burning"
• Gives Isaac a higher chance to find bombs.
• Picking up the Match Stick is the only way to remove the Tick trinket.
A Missing Page
"It glows with power"
• When taking damage, Isaac has a chance to deal damage to the entire room in a Necronomicon style effect.
• The chance to damage enemies is affected by your luck stat and at +50 or more Luck it will activate 50% of the time.
Missing Poster
"???"
• Dying in a sacrifice room while holding this trinket will reveal a puzzle piece on the death screen. Finding all the puzzle pieces will help you to reveal the final secret, unlocking the hidden character 'The Lost'.
UNLOCK: Unlock this item by beating Dark Room with Isaac.
In Afterbirth dying with this trinket causes you to respawn as The Lost character and dying in a sacrafice room while holding this trinket will now unlock the Lost character.
Mom's Pearl
"It emanates purity"
• Higher chance to find Soul Hearts.
Mom's Toenail
"???"
• Mom's Leg will now appear every 60 seconds and stomp down randomly in the room dealing 300 damage to enemies, similar to how Daddy Longlegs works but less frequent.
• Be warned though, Mom's leg can also stomp and hurt Isaac too!
Monkey's Paw
"Wish granted"
• When you reach half a heart of life remaining, a black heart will spawn.
• After three black hearts have spawned, the trinket dissapears.
Mysterious Candy
"Uh-oh!"
• Causes Isaac to create poops randomly.
Mysterious Paper
"???"
• Imitates the behaviours of some of the other 'paper' items/trinkets.
• A Missing Page: When taking damage, Isaac has a chance to deal damage to the entire room in a Necronomicon style effect.
• Has a chance to trigger the Polaroid or Negative effect every time you take damage with half a red heart or less.
• Missing Poster: Dying in a sacrifice room while holding this trinket will reveal a puzzle piece on the death screen. Finding all the puzzle pieces will help you to reveal the final secret, unlocking the hidden character 'The Lost'.
• If held when you touch the chest after the Satan or Isaac fight and you don't have the relevant item to go to the next floor (Polaroid or Negative), you have a small chance to be taken there anyway.
UNLOCK: Unlock this item by beating the Chest with Eden.
Paper Clip
"Master of lockpicking"
• Allows you to unlock golden chests without needing a key.
• Does not work on locked rooms.
In Afterbirth Cain starts with this trinket after donating 68 coins to the Greed Donation Machine.
Petrified Poop
"It feels lucky?"
• While held, Isaac has a significantly higher chance to find drops when breaking poops.
Pinky Eye
"Poison shots"
• Isaac's tears have a chance to poison enemies.
• The poison effect leaves a damage over time, which deals 4 or 6 damage per tick.
• The chance to poison enemies is affected by your luck stat and at +18 Luck it will activate every time.
Pulse Worm
"Wub wub!"
• Tears shrink and grow in size as they go across the room.
• Does not appear to affect your damage and only the hitbox size of tears.
Purple Heart
"Challenge up"
• Higher chance for champion enemies while held.
Push Pin
"Piercing shots"
• Isaac now has a chance to make a spectral and piercing tear.
• The chance to fire a piercing tear is affected by your luck stat and at +18 Luck it will activate every time.
Red Patch
"Your rage grows"
• You have a chance when taking damage to gain +1.8 Damage Up for the rest of the room.
Ring Worm
"Woop woop!"
• While held, tears move in a spiral pattern across the screen at high speed.
• Effectively increases your range due to the tear pattern.
Rosary Bead
"Faith up"
• Increases your chances to find an Angel Room instead of a Devil Room.
• Normally there is a 50%/50% chance of a Angel or Devil room with if a door spawns after the boss. The Rosary Bead changes this to a 75%/25% chance of an angel or devil room (respectively).
Rusted Key
"It feels lucky?"
• Gives Isaac a higher chance to find keys and chests.
Safety Cap
"Don't swallow it"
• Gives Isaac a higher chance to find pills.
Samson's Lock
"Your rage grows"
• When you kill an enemy, you have a chance to get +0.5 damage up for the current room.
UNLOCK: Unlock this item by beating the Dark Room with Samson.
Store Credit
"YES!"
• While this trinket is held, all items in the Shop cost 0 coins.
• After buying any 0 cent item in the Shop, the trinket disappears.
UNLOCK: Unlock this item by beating the Chest with Lazarus.
Swallowed Penny
"Gulp!"
• Each time you get hit, you drop a coin or two.
UNLOCK: Unlock this item by beating Challenge #15 (Slow Roll).
Tick
"Well, that's not coming off"
• When you enter a boss room, immediately remove 15% health from the boss and restore 1 red heart.
• This trinket can only be removed by picking up the Match Stick trinket, meaning you are otherwise unable to take any more trinkets unless you get the Mom's Purse item.
Umbilical Cord
"Fetal protection"
• If you take damage which leaves you at 1/2 a heart, you gain a Little Steve familiar that follows you and shoots homing tears.
Whip Worm
"Wooosh!"
• +0.5 Shot Speed Up.
• Your tears now whip across the room at a very high shot speed.
• Shot speed gives your tears more effective range, but doesn't increase your range stat directly.
Wiggle Worm
"Wiggle wiggle!"
• Tears now move in a wave fashion across the room.
Afterbirth Trinkets
Shiny Rock
"It shines for it's brothers"
• While held, tinted rocks and rocks with a crawlspace below them will flash white every 10 seconds.
Safety Scissors
"Fuse cutter"
• Turns all troll bombs into bombs which you can pick up and use.
• Super Troll bombs turn into 1+1 free double bomb pickups.
Rainbow Worm
"Bleep bloop blop"
• Gives your tears a random worm effect every few seconds.
• The possible tear effects include: Whip Worm, Ring Worm, Wiggle Worm, Flat Worm, Hook Worm, Pulse Worm, Tape Worm and Lazy Worm
Tape Worm
"Floooooooooop!"
• While held, Tape Worm doubles your range stat and halves your tear height stat.
Lazy Worm
"Pft"
• -0.4 Shot Speed Down.
• +4.0 Range Up.
• +2.0 Tear Height.
Cracked Dice
"You feel cursed... kinda."
• Every time you get hit, you have a chance to activate the D6, D20, D8 or D12 effect.
UNLOCK: Unlock this item by beating Greed Mode with ???.
Super Magnet
"It pulls"
• While held this trinket causes all pickups and enemies to move slowly towards you.
• Will also attract the Mom's Foot and Ultra Greed door entities.
Faded Polaroid
"You feel faded"
• Randomly Isaac will gain a camouflage for a few seconds and all enemies in the current room will have a confused status effect applied to them.
Louse
"Itchy, tasty..."
• Gives a small chance to spawn a friendly attack spider while in a hostile room with enemies.
Bob's Bladder
"Creepy bombs"
• Leaves a pool of green creep under all bombs you place, which damages enemies that walk over it.
Watch Battery
"Lil charge"
• Gives you an increased chance of finding battery consumables.
Blasting Cap
"Pop! Pop!"
• Exploding bombs now have a chance to drop another bomb that you can pick up.
Stud Finder
"The ground below feels hollow..."
• Higher chance to find crawl spaces when exploding rocks.
UNLOCK: Unlock this card by beating Challenge #27 (Brains).
Error
"Effect not found?"
• Gives a different trinket effect per room, randomly choosing between any of the other available trinkets in the game.
• Each room is locked to a specific trinket effect, meaning if you exit and re-enter a room, that specific room will always have the same effect.
Poker Chip
"It's double down time!"
• Chests now have a 50/50 chance to either pay out with extra consumables or nothing/an enemy.
UNLOCK: Unlock this card by beating Challenge #26 (I Rule).
Blister
"Bounce back!"
• Tears have a stronger knockback effect while this trinket is held
Second Hand
"Extended stat effect time"
• Increases the time that status effects stay on enemies. e.g. With poison effects, the damage over time poison will last for much longer.
Endless Nameless
"I'm stuck in a loop..."
• While held there is a small chance when using a tarot card or pill that a copy of it will be dropped on the floor next to you.
Black Feather
"With darkness comes power"
• +0.2 Damage Up for each 'evil' item you have.
• Items classed as evil in this case are Black Candle, Ceremonial Robes, Abaddon, Goat Head, Match Book, Missing Page 2, Safety Pin.
UNLOCK: Unlock this item by beating Greed Mode with Eve.
Blind Rage
"Blind to damage"
• Invincibility lasts longer after getting hit (Increased i-frames)
• This makes it possible to use the Blood Donation machine twice from one hit of damage.
UNLOCK: Unlock this item by beating Blue Womb (Hush) with Samson.
Golden Horse Shoe
"Feel lucky?"
• +15% chance to get a double item room to spawn on the next floor.
• If the effect activates, two items spawn in your item room, however only one can be taken (Same effect as the More Options item)
• The chance doubles to +30% with the effect from Mom's Box.
Store Key
"Stores are open"
• Automatically opens all shop room doors for free.
UNLOCK: Unlock this trinket by donating 666 coins to the Greed Donation Machine.
UNLOCK: Keeper starts with this trinket after beating Satan with Keeper.
Rib of Greed
"Feels greedy"
• Forces the Greed and Super Greed mini bosses to no longer appear in shops or secret rooms.
UNLOCK: Unlock this trinket by beating Ultra Greed with Keeper.
Karma
"Karma up"
• Donating to a Donation Machine has a chance to heal Isaac for a full red heart or spawn a Beggar.
UNLOCK: Unlock this item by beating The Lamb boss with Keeper.
Lil Larva
"the poop is moving..."
• Destroying poops now gives you a blue fly
Mom's Locket
"you feel her love"
• While held, you heal for half a red heart every time you use a key to open a door or golden chest.
• Changes all half red hearts into full hearts.
NO!
"Never again!"
• While this trinket is held you have a significantly lower chance to find spacebar/active items.
• It will cause passive items to spawn except when the game cannot generate any more passive items and will then instead choose spacebar/active items.
• Some hard coded spacebar items from bosses and mini-bosses (i.e. Krampus Head) can still spawn.
• Bible drops caused by the Rosary item are not prevented by this trinket.
Child Leash
"Keep your friends close..."
• Causes your familiars to stay closer to each other.
Brown Cap
"Fartoom!"
• Poop in the environment will now explode when destroyed.
Consumables + Misc.
O - The Fool
"Where your journey begins"
• Teleports the player to the first room of the current floor.
I - The Magician
"May you never miss your goal"
• For the current room, tears now have the Spoon Bender effect, which allows them to curve towards enemies and gives them a purрle appearance.
II - The High Priestess
"Mother is watching you"
• Summons Mom's foot which will stomp on a random enemy in the current room, dealing 300 damage.
• If no enemies are in the current room, the foot will target Isaac (and do damage if it hits), however it can be used to break rocks.
III - The Empress
"May your rage bring power"
• Gives the player the Whore of Babylon effect for the current room, increasing damage and speed.
IV - The Emperor
"Challenge me!"
• Teleports the player to the Boss room on the current floor.
V - The Hierophant
"Two prayers for the lost"
• Spawns 2 Soul hearts on the floor.
VI - The Lovers
"May you prosper and be in good health"
• Spawns 2 red hearts on the floor.
VII - The Chariot
"May nothing stand before you"
• Grants the same effect as 'My Little Unicorn', which makes Isaac invincible and deal 40 contact damage to enemies per hit.
VIII - Justice
"May your future become balanced"
• Spawns 1 bomb, 1 key, 1 coin, 1 heart, which can be random variants of each.
IX - The Hermit
"May you see what life has to offer"
• Teleports the player to the Shop.
• On or below the Womb, this acts as a random teleport, since there are no shops on those floors.
X - Wheel of Fortune
"Spin the wheel of destiny"
• Spawns a Slot Machine or a Fortune Machine.
XI - Strength
"May your power bring rage"
• Gives the player the Magic Mushroom effect, which increasing size and all stats by 1 for the current room.
• If you use the Strength card with 12 heart containers, it will take you down to 11 when you leave the room.
XII - The Hanged Man
"May you find enlightenment"
• Gives the player the flying effect for the current room, allowing the player to fly over obstacles in the room.
• This card is useless if you have any item which allows you to permanently fly.
XIII - Death
"Lay waste to all that oppose you"
• Deals 40 damage to all enemies in the room in a similar style to the Necronomicon.
XIV - Temperance
"May you be pure in heart"
• Spawns a Blood Donation Machine.
XV - The Devil
"Revel in the power of your darkness"
• Gives the Book of Belial effect for the current room, increasing damage.
XVI - The Tower
"Destruction brings creation"
• Spawns some troll bombs at random locations in the current room.
• Each bomb deals 60 damage (normal bomb damage.
XVII - The Stars
"May you find what you desire"
• Teleports the player to the Item Room.
• On or below the Womb, this acts as a random teleport, since there are no item rooms on those floors.
XVIII - The Moon
"May you find all you have lost"
• Teleports the player to the Secret Room.
XIX - The Sun
"May the light heal and enlighten you"
• A card with three uses: A full heal, deals 100 damage to all enemies in the current room and reveals the entire map for the current floor (Treasure Map + The Compass).
XX - Judgement
"Judge lest ye be judged"
• Spawns a beggar.
• Has a chance to be a demon beggar.
• Killing a Devil Beggar, Key Master, or Shell Game Beggar gives you an increased chance of finding Angel rooms instead of Devil rooms. See the dedicated Devil room page for more details.
XXI - The World
"Open your eyes and see"
• Reveals the entire map and shows the icons for every room which has one.
• This is completely useless if you currently have both the Treasure Map and The Compass.
2 of Spades
"Item multiplier"
• Doubles the number of keys you have.
• If you have no keys, it gives you two.
2 of Clubs
"Item multiplier"
• Doubles the number of Bombs you have.
• If you have no bombs, it gives you two.
2 of Hearts
"Item multiplier"
• Doubles your current red hearts up to full health.
• This card is useless for the Bluе Baby.
2 of Diamonds
"Item multiplier"
• Doubles the number of coins you have.
• If you have no coins, it gives you two.
The Joker
"???"
• Teleports you to the Devil Deal Room on the current floor.
Chaos Card
"???"
• A card which can be thrown as a projectile directly infront of Isaac, instantly killing anything it hits.
• ...Yes that includes every boss in the game!
• If thrown at a multi-phase boss like Satan, it will only kill that particular phase of the boss.
• Will destroy rocks and poop in its path.
• Can also be thrown against a door to open it (Doesn't work against Mega Satan's door).
UNLOCK: Unlock this card by beating Challenge #9 (Demo Man).
Credit Card
"Charge it!"
• When used, removes the price tag from all items in the current shop or devil deal, making everything free.
• The effect of the Credit Card only lasts for the current room.
UNLOCK: Unlock this card by beating Challenge #10 (Cursed!).
Rules Card
"???"
• Displays a random cryptic message on the screen similar to the fortune machine ones. One of the following messages may show:
• "Rooms may yield more than you expect"
• "Some doors require a blessing. Carry them with you"
• "The walls will harden over time. Time is the essence"
• "Sleeping gatekeepers will need to be awoken with a loud sound"
• A piece of paper is your guide"
• Deny his gifts to attain your reward"
• A dark market lies under your feet
• Chub dislikes smoke!
UNLOCK: Unlock this card by beating Challenge #11 (Glass Cannon).
Card Against Humanity
"Something stinks..."
• When used, fills the entire room with poop!
UNLOCK: Unlock this card by beating Challenge #12 (When Life Gives You Lemons).
Suicide King
"A true ending?"
• When used, instantly kills you and spawns 10 pickup on the floor.
• Each of the 10 things spawned can be any type of consumable or sometimes a pedestal item (up to a maximum of 3 pedestal items).
• Any pedestal item created by Suicide King will be related to the room where it was used, meaning that using it in the Angel room will spawn Angel room items.
UNLOCK: Unlock this card by beating Challenge #7 (Suicide King).
Rune of Algiz
"Resistance"
• When used, gives you an invincibility effect which lasts for 30 seconds (much longer than normal invincibility effects).
UNLOCK: Unlock this card by beating Challenge #8 (Cat Got Your Tongue).
Rune of Ansuz
"Vision"
• When used, reveals the entire map including all the secret room locations and other icon rooms.
UNLOCK: Unlock this card by beating Challenge #5 (The Tank).
Rune of Berkano
"Companionship"
• Summons 3 blue friendly spiders and 3 blue flies.
UNLOCK: Unlock this card by beating Challenge #20 (Purist).
Rune of Dagaz
"Purity"
• Removes the curse which is in effect on the current floor.
• Can also cure the effect of the Amnesia pill.
• +1 Soul Heart.
UNLOCK: Unlock this card by beating Challenge #4 (Darkness Falls).
Rune of Ehwaz
"Passage"
• Creates a trapdoor on the floor (Same effect as We Need To Go Deeper).
UNLOCK: Unlock this card by beating Challenge #3 (Head Trauma).
Rune of Hagalaz
"Destruction"
• When used, this rune will destroy all breakable objects in the current room, such as poop, rocks and skulls.
UNLOCK: Unlock this card by beating Challenge #1 (Pitch Black).
Rune of Jera
"Abundance"
• When used this rune will double all pickups on the floor in the room.
• Creates copies of pickups, even if you haven't purchased them yet.
• Can be used to double the number of golden item chests in the first room of the final Chest floor.
UNLOCK: Unlock this card by beating Challenge #2 (High Brow).
Rune of Perthro
"Change"
• Rerolls all pedestal items in the current room (One time use of the D6).
UNLOCK: Unlock this card by beating Challenge #6 (Solar System).
Dice Rooms
• 1 Dot - Rerolls all of your items. (Does not change your trinkets, pills or cards)
• 2 Dot - Rerolls all pickups in the room. (D20 effect)
• 3 Dot - Rerolls all pickups on the entire floor.
• 4 Dot - Rerolls all pedestal items on the floor. (Does not roll your devil deal items)
• 5 Dot - Reroll and restart the current floor (Forget Me Now effect).
• 6 Dot - Reroll all of your items and all the pickups on the entire floor (Combined 1 + 3 + 4 rooms).
Blank Rune
"???"
• When used, gives a random Mystic rune effect.
• Possible effects include: Algiz, Ansuz, Berkano, Dagaz, Ehwaz, Hagalaz, Jera, Perthro.
• Also has a 25% chance to spawn another Blank Rune upon use.
UNLOCK: Unlock this card by beating Challenge #30 (Guardian).
Dice Shard
• Gives a one-time use of the D6 and D20 effects at the same time.
Get Out Of Jail Free Card
"Open sesame"
• When used, will open all doors in the current room, similar to a one-time use of Dad's Key.
UNLOCK: Unlock this card by beating Challenge #22 (Speed).
? Card
"Double active"
• When used this card will activate a use of your spacebar item for free.
Emergency Contact
"Help from above"
• When used will cause two of Mom's Hand to come down and grab a random enemy.
Gold Key
• Once picked up, you gain unlimited key use for the rest of the floor.
Gold Heart
• Once picked up, the gold heart will drop money on the floor the next time Isaac loses a heart.
UNLOCK: Unlock this item by beating challenge #21 (XXXXXXXXL).
Gold Bomb
• Once picked up, you gain unlimited bomb use for the rest of the floor.
UNLOCK: Unlock this item by beating challenge #23 (Blue Bomber).